Targeting the Achilles' heel of hepatitis C virus

被引：5

作者：

Lemon, SM ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC

来源：

HEPATOLOGY | 1997年 / 25卷 / 04期

关键词：

D O I：

10.1002/hep.510250441

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：1035 / 1037

页数：3

共 10 条

[1] NONSTRUCTURAL PROTEIN-3 OF THE HEPATITIS-C VIRUS ENCODES A SERINE-TYPE PROTEINASE REQUIRED FOR CLEAVAGE AT THE NS3/4 AND NS4/5 JUNCTIONS [J].

BARTENSCHLAGER, R ;

AHLBORNLAAKE, L ;

MOUS, J ;

JACOBSEN, H .

JOURNAL OF VIROLOGY, 1993, 67 (07) :3835-3844

[2]

Blundell TL, 1996, NATURE, V384, P23

[3] CHARACTERIZATION OF THE HEPATITIS-C VIRUS-ENCODED SERINE PROTEINASE - DETERMINATION OF PROTEINASE-DEPENDENT POLYPROTEIN CLEAVAGE SITES [J].

GRAKOUI, A ;

MCCOURT, DW ;

WYCHOWSKI, C ;

FEINSTONE, SM ;

RICE, CM .

JOURNAL OF VIROLOGY, 1993, 67 (05) :2832-2843

[4] A 2ND HEPATITIS-C VIRUS-ENCODED PROTEINASE [J].

GRAKOUI, A ;

MCCOURT, DW ;

WYCHOWSKI, C ;

FEINSTONE, SM ;

RICE, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (22) :10583-10587

[5] Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity [J].

Hahm, B ;

Back, SH ;

Lee, TG ;

Wimmer, E ;

Jang, SK .

VIROLOGY, 1996, 226 (02) :318-326

[6] 2 DISTINCT PROTEINASE ACTIVITIES REQUIRED FOR THE PROCESSING OF A PUTATIVE NONSTRUCTURAL PRECURSOR PROTEIN OF HEPATITIS-C VIRUS [J].

HIJIKATA, M ;

MIZUSHIMA, H ;

AKAGI, T ;

MORI, S ;

KAKIUCHI, N ;

KATO, N ;

TANAKA, T ;

KIMURA, K ;

SHIMOTOHNO, K .

JOURNAL OF VIROLOGY, 1993, 67 (08) :4665-4675

[7] Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide [J].

Kim, JL ;

Morgenstern, KA ;

Lin, C ;

Fox, T ;

Dwyer, MD ;

Landro, JA ;

Chambers, SP ;

Markland, W ;

Lepre, CA ;

OMalley, ET ;

Harbeson, SL ;

Rice, CM ;

Murcko, MA ;

Caron, PR ;

Thomson, JA .

CELL, 1996, 87 (02) :343-355

[8] A CENTRAL REGION IN THE HEPATITIS-C VIRUS NS4A PROTEIN ALLOWS FORMATION OF AN ACTIVE NS3-NS4A SERINE PROTEINASE COMPLEX IN-VIVO AND IN-VITRO [J].

LIN, C ;

THOMSON, JA ;

RICE, CM .

JOURNAL OF VIROLOGY, 1995, 69 (07) :4373-4380

[9] The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site [J].

Love, RA ;

Parge, HE ;

Wickersham, JA ;

Hostomsky, Z ;

Habuka, N ;

Moomaw, EW ;

Adachi, T ;

Hostomska, Z .

CELL, 1996, 87 (02) :331-342

[10] STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE [J].

WLODAWER, A ;

ERICKSON, JW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 :543-585

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