Intersex condition and molecular markers of endocrine disruption in relation with burdens of emerging pollutants in thicklip grey mullets (Chelon labrosus) from Basque estuaries (South-East Bay of Biscay)

被引：55

作者：

Bizarro, C. ^{[1
,2
]}

Ros, O. ^{[3
]}

Vallejo, A. ^{[3
]}

Prieto, A. ^{[3
]}

Etxebarria, N. ^{[2
,3
]}

Cajaraville, M. P. ^{[1
,2
]}

Ortiz-Zarragoitia, M. ^{[1
,2
]}

机构：

[1] Univ Basque Country UPV EHU, Dep Zool & Cell Biol, Fac Sci & Technol, E-48940 Leioa, Basque Country, Spain

[2] Univ Basque Country, Res Ctr Expt Marine Biol & Biotechnol PIE, E-48620 Plentzia, Basque Country, Spain

[3] Univ Basque Country UPV EHU, Dep Analyt Chem, Fac Sci & Technol, E-48940 Leioa, Basque Country, Spain

来源：

MARINE ENVIRONMENTAL RESEARCH | 2014年 / 96卷

关键词：

Endocrine disrupting chemicals; Intersex; Vitellogenin; Aromatase cyp19a1b; Chelon labrosus; Bile analytes; Water chemistry; Bay of Biscay; Fish; MUNICIPAL WASTE-WATER; MUGIL-CEPHALUS; FISH BILE; ESTROGENIC SUBSTANCES; COASTAL WATERS; ACUTE TOXICITY; RED MULLET; WILD FISH; IDENTIFICATION; CHEMICALS;

D O I：

10.1016/j.marenvres.2013.10.009

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Endocrine disrupting chemicals (EDCs) interfere with the functioning of the endocrine system, causing reproductive and developmental disturbances in aquatic wildlife. Appearance of intersex gonads and elevated plasma levels of vitellogenin in male fish are well known biomarkers of exposure to xenoestrogenic EDCs. In the present study, intersex condition and transcription levels of vtg and cyp19a1b were assessed in five thicklip grey mullet populations from the Basque coast (Bay of Biscay). Levels of EDCs (estrogenic hormones, polycyclic musks, bisphenol-A, phthalates, alkylphenols and pesticides) were determined in water and fish bile. Intersex gonads were observed in three out of five mullet populations. Vtg and cyp19a1b were up-regulated in mullet populations with relatively higher EDCs load. Phthalates and pesticides were the most abundant EDCs in bile, followed by alkylphenols, musks, bisphenol-A and estrogenic hormones. Statistically significant correlations were found between concentrations of individual and total EDCs in bile and water samples and transcription levels of vtg and cyp19a1b. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：19 / 28

页数：10

共 61 条

[1] Survey of contamination of estrogenic chemicals in Japanese and Korean coastal waters using the wild grey mullet (Mugil cephalus) [J].