Apoptosis-Inducing Effects of Melissa officinalis L. Essential Oil in Glioblastoma Multiforme Cells

被引：32

作者：

de Queiroz, Rafaela Muniz ^{[1
]}

Takiya, Christina Maeda ^{[1
]}

Tavares Pacheco Guimaraes, Livia Paes ^{[1
]}

Rocha, Gleice da Graca ^{[1
]}

Alviano, Daniela Sales ^{[2
]}

Blank, Arie Fitzgerald ^{[3
]}

Alviano, Celuta Sales ^{[2
]}

Gattass, Cerli Rocha ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, Lab Imunol Celular, BR-21941 Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Lab Estruturas Superficie Microorganimos, Ctr Ciencias Saude, Inst Microbiol Prof Paulo de Gois, BR-21941 Rio De Janeiro, RJ, Brazil

[3] Univ Fed Sergipe, Dept Engn Agron, Sao Cristovao, SE, Brazil

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 06期

关键词：

Chemotherapy; Gliobastoma multiforme; Melissa officinali essential oil; Citral; ANTICANCER DRUGS; ABC TRANSPORTERS; P-GLYCOPROTEIN; RESISTANCE; EXPRESSION; INDUCTION; PROTEIN-1; PATHWAYS; SURVIVAL; THERAPY;

D O I：

10.3109/07357907.2014.905587

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and caspase-3 activation. Antioxidant prevented citral-induced death, indicating its dependence on the production of reactive oxygen species. Citral downmodulated the activity and inhibited the expression of multidrug resistance associated protein 1 (MRP1). These results show that EO, through its major component, citral, may be of potential interest for the treatment of GBM.

引用

页码：226 / 235

页数：10

共 31 条

[1] Expression of multidrug resistance protein gene in patients with glioma after chemotherapy [J].