The interaction between smoking and Epstein-Barr virus as multiple sclerosis risk factors may depend on age

被引：18

作者：

Salzer, Jonatan ^{[1
]}

Stenlund, Hans ^{[2
]}

Sundstrom, Peter ^{[1
]}

机构：

[1] Umea Univ, Neurol Sect, Dept Pharmacol & Clin Neurosci, SE-90187 Umea, Sweden

[2] Umea Univ, Dept Publ Hlth & Clin Med, SE-90187 Umea, Sweden

来源：

MULTIPLE SCLEROSIS JOURNAL | 2014年 / 20卷 / 06期

关键词：

Epstein-Barr virus; case control study; interaction; risk factors in epidemiology; smoking; Multiple sclerosis; VITAMIN-D; ANTIBODIES;

D O I：

10.1177/1352458513507820

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The multiple sclerosis (MS) risk factors smoking and remote Epstein-Barr virus (EBV) infection have been suggested to interact statistically, but the results are conflicting. In a prospective study on 192 MS cases and 384 matched controls, we analysed levels of cotinine as a marker of smoke exposure, and Epstein-Barr Nuclear Antigen-1 antibody reactivity. We assessed interaction on the additive and multiplicative scales, and estimated the effects of the risk factors across strata of each other. The results suggest that a negative interaction may be present in samples drawn at a young age, and a positive interaction among older subjects.

引用

页码：747 / 750

页数：4

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