Invertible Amphiphilic Molecular Pockets Made of Cholic Acid

被引：34

作者：

Luo, Juntao ^{[1
]}

Chen, Yilong ^{[1
]}

Zhu, X. X. ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

LANGMUIR | 2009年 / 25卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

UMBRELLA-ASSISTED TRANSPORT; ONE-POT SYNTHESIS; INCLUSION COMPLEXES; BETA-CYCLODEXTRIN; ION CHANNELS; DENDRITIC POLY(AMIDE-UREA)S; CURTIUS REARRANGEMENT; PHOSPHOLIPID-BILAYERS; REVERSED MICELLES; DERIVATIVES;

D O I：

10.1021/la9013703

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A trimer of cholic acid was prepared via a simple isocyanate linkage. Fluorescence and UV-vis spectroscopic studies showed that the same cholane trimer can form either a hydrophobic cavity in aqueous solutions or a hydrophilic cavity in an apolar solvent using pyrene and a derivative of pyrene as probes. The dynamic inversion of the cavities was demonstrated for the first time by a simple change of the polarity of the solvent media by adjusting from an aqueous buffer to tetrahydrofuran and vice versa. The NMR study of a dimer model compound of cholic acid indicated a restricted conformation exist in the solvent mixture of chloroform and methanol.

引用

页码：10913 / 10917

页数：5

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