Room-temperature AuI-catalyzed C-C bond formation through a tandem Friedel-Crafts-type addition/carbocyclization reaction

被引：147

作者：

Toullec, Patrick Yves ^{[1
]}

Genin, Emilie ^{[1
]}

Leseurre, Lucie ^{[1
]}

Genet, Jean-Pierre ^{[1
]}

Michelet, Veronique ^{[1
]}

机构：

[1] Ecole Natl Super Chim Paris, Lab Synth Select Organ & Prod Nat, UMR 7573, F-75231 Paris 05, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 44期

关键词：

arenes; C-H activation; cyclization; gold; tandem reaction;

D O I：

10.1002/anie.200601980

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A golden tandem reaction: The [PPh 3AuCl]/AgSbF6 catalytic system promotes a tandem reaction composed of a Friedel-Crafts-type addition of electron-rich aromatic and heteroaromatic derivatives to unactivated alkenes and a carbocyclization (see scheme; Z = C(CO2Me)2, C(SO2Ph)2, O, NTs). The reaction is compatible with various functional groups on the enynes and nucleophiles, and proceeds rapidly at room temperature. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7427 / 7430

页数：4

共 67 条

[11] Ru(II)- and Pt(II)-catalyzed cycloisomerization of ω-aryl-1-alkynes.: Generation of carbocationic species from alkynes and transition metal halides and its interception by an aromatic ring [J].