Enhanced release rate of the poorly water-soluble ginsenoside Rg3 with ordered meso/macroporous silica

被引：0

作者：

Wu, Ming ^{[1
]}

Xu, Jing ^{[1
]}

Lin, Xiong ^{[1
]}

Zhan, Xin ^{[1
]}

Xiao, Kunyu ^{[1
]}

Lei, Lin ^{[1
]}

Li, Shuiqing ^{[1
]}

Liu, Yanju ^{[1
]}

机构：

[1] Hubei Univ Chinese Med, Pharm Fac, Wuhan 430065, Hubei, Peoples R China

来源：

JOURNAL OF POROUS MATERIALS | 2021年 / 28卷 / 03期

关键词：

Ordered meso; Macroporous drug; Hierarchical structure; Dissolution rate; Ginsenoside Rg3; Silica-ginsenoside; MESOPOROUS CARBON; DRUG; CARRIER; CANCER; SBA-15;

D O I：

10.1007/s10934-020-01025-5

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Although ginsenoside Rg3 is very important in pharmaceutical field, the application of this drug is greatly limited by the release rate due to its poor dissolution. Here we introduced a meso/macroporous SiO2 to assist dispersing Rg3. The as-obtained SiO2/Rg3 (m/M-SiO2/Rg3) with this well-designed support showed superior Rg3 release rate compared to a mesoporous SiO2/Rg3 (m-SiO2/Rg3) at the same release duration and Rg3 loading 20 wt%. The excellent performance of the carrier drug could be attributed to the structural characteristics of hierarchically porous SiO2. On one hand, the macropores (similar to 270 nm) accommodate for the active ingredient as effective reservoirs, more importantly the interconnected macropores efficiently shortens the paths of transferring Rg3, which facilitates releasing Rg3 at the nearest mesoporous channels (similar to 2.8 nm) penetrated on the wall of adjacent macropores.

引用

页码：711 / 716

页数：6

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