Management of cytokine release syndrome: an update on emerging antigen-specific T cell engaging immunotherapies

被引：55

作者：

Khadka, Roman H. ^{[1
,2
]}

Sakemura, Reona ^{[3
]}

Kenderian, Saad S. ^{[2
,3
]}

Johnson, Aaron J. ^{[2
,4
]}

机构：

[1] Mayo Clin, Grad Sch Biomed Sci, 200 First St SW, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Immunol, 200 First St SW, Rochester, MN 55905 USA

[3] Mayo Clin, Div Hematol, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Neurol, 200 First St SW, Rochester, MN 55905 USA

来源：

IMMUNOTHERAPY | 2019年 / 11卷 / 10期

关键词：

bispecific T cell engager; BiTE; CAR T cells; chimeric antigen receptor; CRS; cytokine release syndrome; immunotherapy; neurotoxicity; BLINATUMOMAB; ACTIVATION; THERAPY; SYSTEM;

D O I：

10.2217/imt-2019-0074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：851 / 857

页数：7

共 22 条

[1] T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma [J].

Brudno, Jennifer N. ;

Maric, Irina ;

Hartman, Steven D. ;

Rose, Jeremy J. ;

Wang, Michael ;

Lam, Norris ;

Stetler-Stevenson, Maryalice ;

Salem, Dalia ;

Yuan, Constance ;

Pavletic, Steven ;

Kanakry, Jennifer A. ;

Ali, Syed Abbas ;

Mikkilineni, Lekha ;

Feldman, Steven A. ;

Stroncek, David F. ;

Hansen, Brenna G. ;

Lawrence, Judith ;

Patel, Rashmika ;

Hakim, Frances ;

Gress, Ronald E. ;

Kochenderfer, James N. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (22) :2267-+

[2] CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade [J].

Giavridis, Theodoros ;

van der Stegen, Sjoukje J. C. ;

Eyquem, Justin ;

Hamieh, Mohamad ;

Piersigilli, Alessandra ;

Sadelain, Michel .

NATURE MEDICINE, 2018, 24 (06) :731-+

[3] Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells [J].

Gust, Juliane ;

Hay, Kevin A. ;

Hanafi, Laila-Aicha ;

Li, Daniel ;

Myerson, David ;

Gonzalez-Cuyar, Luis F. ;

Yeung, Cecilia ;

Liles, W. Conrad ;

Wurfel, Mark ;

Lopez, Jose A. ;

Chen, Junmei ;

Chung, Dominic ;

Harju-Baker, Susanna ;

Tzpolat, Tahsin ;

Fink, Kathleen R. ;

Riddell, Stanley R. ;

Maloney, David G. ;

Turtle, Cameron J. .

CANCER DISCOVERY, 2017, 7 (12) :1404-1419

[4] Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria [J].

Huggins, Matthew A. ;

Johnson, Holly L. ;

Jin, Fang ;

Songo, Aurelie N. ;

Hanson, Lisa M. ;

LaFrance, Stephanie J. ;

Butler, Noah S. ;

Harty, John T. ;

Johnson, Aaron J. .

INFECTION AND IMMUNITY, 2017, 85 (05)

[5] Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia [J].

Kantarjian, Hagop ;

Stein, Anthony ;

Goekbuget, Nicola ;

Fielding, Adele K. ;

Schuh, Andre C. ;

Ribera, Josep-Maria ;

Wei, Andrew ;

Dombret, Herve ;

Foa, Robin ;

Bassan, Renato ;

Arslan, Onder ;

Sanz, Miguel A. ;

Bergeron, Julie ;

Demirkan, Fatih ;

Lech-Maranda, Ewa ;

Rambaldi, Alessandro ;

Thomas, Xavier ;

Horst, Heinz-August ;

Brueggemann, Monika ;

Klapper, Wolfram ;

Wood, Brent L. ;

Fleishman, Alex ;

Nagorsen, Dirk ;

Holland, Christopher ;

Zimmerman, Zachary ;

Topp, Max S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (09) :836-847

[6] Ruxolitinib Prevents Cytokine Release Syndrome after CART Cell Therapy without Impairing the Anti-Tumor Effect in a Xenograft Model [J].

Kenderian, Saad S. ;

Ruella, Marco ;

Shestova, Olga ;

Kim, Miriam Y. ;

Klichinsky, Michael ;

Chen, Fang ;

Kengle, Natalka ;

Lacey, Simon Francis ;

Melenhorst, J. Joseph ;

June, Carl H. ;

Gill, Saar I. .

BLOOD, 2016, 128 (22)

[7] ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells [J].

Lee, Daniel W. ;

Santomasso, Bianca D. ;

Locke, Frederick L. ;

Ghobadi, Armin ;

Turtle, Cameron J. ;

Brudno, Jennifer N. ;

Maus, Marcela, V ;

Park, Jae H. ;

Mead, Elena ;

Pavletic, Steven ;

Go, William Y. ;

Eldjerou, Lamis ;

Gardner, Rebecca A. ;

Frey, Noelle ;

Curran, Kevin J. ;

Peggs, Karl ;

Pasquini, Marcelo ;

DiPersio, John F. ;

van den Brink, Marcel R. M. ;

Komanduri, Krishna, V ;

Grupp, Stephan A. ;

Neelapu, Sattva S. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (04) :625-638

[8] Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial [J].

Locke, Frederick L. ;

Ghobadi, Armin ;

Jacobson, Caron A. ;

Miklos, David B. ;

Lekakis, Lazaros J. ;

Oluwole, Olalekan O. ;

Lin, Yi ;

Braunschweig, Ira ;

Hill, Brian T. ;

Timmerman, John M. ;

Deol, Abhinav ;

Reagan, Patrick M. ;

Stiff, Patrick ;

Flinn, Ian W. ;

Farooq, Umar ;

Goy, Andre ;

McSweeney, Peter A. ;

Munoz, Javier ;

Siddiqi, Tanya ;

Chavez, Julio C. ;

Herrera, Alex F. ;

Bartlett, Nancy L. ;

Wiezorek, Jeffrey S. ;

Navale, Lynn ;

Xue, Allen ;

Jiang, Yizhou ;

Bot, Adrian ;

Rossi, John M. ;

Kim, Jenny J. ;

Go, William Y. ;

Neelapu, Sattva S. .

LANCET ONCOLOGY, 2019, 20 (01) :31-42

[9] Complete Hematologic and Molecular Response in Adult Patients With Relapsed/Refractory Philadelphia Chromosome-Positive B-Precursor Acute Lymphoblastic Leukemia Following Treatment With Blinatumomab: Results From a Phase II, Single-Arm, Multicenter Study [J].

Martinelli, Giovanni ;

Boissel, Nicolas ;

Chevallier, Patrice ;

Ottmann, Oliver ;

Goekbuget, Nicola ;

Topp, Max S. ;

Fielding, Adele K. ;

Rambaldi, Alessandro ;

Ritchie, Ellen K. ;

Papayannidis, Cristina ;

Sterling, Lulu Ren ;

Benjamin, Jonathan ;

Stein, Anthony .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (16) :1795-+

[10] Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2 [J].

Morgan, Richard A. ;

Yang, James C. ;

Kitano, Mio ;

Dudley, Mark E. ;

Laurencot, Carolyn M. ;

Rosenberg, Steven A. .

MOLECULAR THERAPY, 2010, 18 (04) :843-851

← 1 2 3 →