Acyclic Cucurbit[n]uril Dendrimers

被引：4

作者：

Sigwalt, David ^{[1
]}

Ahlbrand, Sarah ^{[2
]}

Zhang, Mingming ^{[1
]}

Vinciguerra, Brittany ^{[1
]}

Briken, Volker ^{[2
]}

Isaacs, Lyle ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

[2] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 23期

关键词：

MOLECULAR CONTAINERS INFLUENCE; HOST-GUEST COMPLEXATION; GENE DELIVERY; SOLUBILIZING EXCIPIENTS; CUCURBITURIL HOMOLOGS; DRUG-DELIVERY; DRIVING-FORCE; SYSTEMS; RELEASE; DERIVATIVES;

D O I：

10.1021/acs.orglett.5b03145

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of acyclic cucurbit[n]uril dendrirners G1-G3 that bear four dendrons on their aromatic sidewalls via thiolate S(N)2 chemistry is reported. G1-G3 are polycationic and can bind to pEGFP plasmid DNA as shown by dynamic light scattering (DLS), gel electrophoresis, and scanning electron microscopy (SEM). The gene delivery ability of G1-G3 is presented.

引用

页码：5914 / 5917

页数：4

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