Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment

被引：23

作者：

Patel, A ^{[1
]}

Harrison, E ^{[1
]}

Durward, A ^{[1
]}

Murdoch, IA ^{[1
]}

机构：

[1] Guys Hosp, Dept Paediat Intens Care, London SE1 9RT, England

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2000年 / 84卷 / 04期

关键词：

complications; asthma; children; enzymes; recombinant human deoxyribonuclease;

D O I：

10.1093/oxfordjournals.bja.a013479

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.

引用

页码：505 / 507

页数：3

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