Innovative lead discovery strategies for tropical diseases

被引：429
作者：
Nwaka, Solomon [1 ]
Hudson, Alan [1 ]
机构：
[1] World Hlth Org, Special Programme Res & Training Trop Dis, Geneva, Switzerland
来源：
NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 11期
关键词：
D O I：
10.1038/nrd2144
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Lead discovery is currently a key bottleneck in the pipeline for much-needed novel drugs for tropical diseases such as malaria, tuberculosis, African sleeping sickness, leishmaniasis and Chagas disease. Here, we discuss the different approaches to lead discovery for tropical diseases and emphasize a coordination strategy that involves highly integrated partnerships and networks between scientists in academic institutions and industry in both wealthy industrialized countries and disease-endemic countries. This strategy offers the promise of reducing the inherently high attrition rate of the early stages of discovery research, thereby increasing the chances of success and enhancing cost-effectiveness.
引用
收藏
页码：941 / 955
页数：15
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