MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients

被引：6

作者：

Pichiecchio, A. ^{[1
]}

Tavazzi, E. ^{[2
]}

Maccabelli, G. ^{[1
]}

Ponzio, M. ^{[3
]}

Romani, A. ^{[2
]}

Schiappacassa, R. ^{[1
]}

Poloni, G. U. ^{[1
]}

Franciotta, D. ^{[4
]}

Roccatagliata, L. ^{[5
]}

Bergamaschi, R. ^{[2
]}

Bastianello, S. ^{[1
]}

机构：

[1] Univ Pavia, Neurol Inst IRCCS Fdn C Mondino, Neuroradiol Unit, I-27100 Pavia, Italy

[2] Neurol Inst IRCCS Fdn C Mondino, Multiple Sclerosis Ctr, Pavia, Italy

[3] Univ Pavia, Dept Hlth Sci, Unit Med Stat & Epidemiol, I-27100 Pavia, Italy

[4] Univ Pavia, Neurol Inst IRCCS Fdn C Mondino, Lab Neuroimmunol, I-27100 Pavia, Italy

[5] Dept Neurosci Ophthalmol & Genet, Genoa, Italy

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2009年 / 120卷 / 04期

关键词：

immunoglobulin G; magnetic resonance imaging; multiple sclerosis; oligoclonal bands; CEREBROSPINAL-FLUID; DIAGNOSIS;

D O I：

10.1111/j.1600-0404.2008.01147.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives - We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods - We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results - Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB-) (P = 0.004), but we did not find a significant difference for their median volume (P = 0.553) and median number (P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution (P = 1.00) and no significant difference in the median volume (P = 0.818) and number (P = 0.643) between the two groups. Conclusions - The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.

引用

页码：242 / 245

页数：4

共 14 条

[1] PERIVENTRICULAR LESIONS IN MULTIPLE-SCLEROSIS - THEIR PERIVENOUS ORIGIN AND RELATIONSHIP TO ANTIGRANULOCYTES EPENDYMITIS [J].