Comprehensive Characterization of Linalool-HP-β-Cyclodextrin Inclusion Complexes

被引：26

作者：

Isabel Rodriguez-Lopez, Maria ^{[1
]}

Teresa Mercader-Ros, Maria ^{[1
]}

Lucas-Abellan, Carmen ^{[1
]}

Antonio Pellicer, Jose ^{[1
]}

Perez-Garrido, Alfonso ^{[2
]}

Perez-Sanchez, Horacio ^{[2
]}

Josefa Yanez-Gascon, Maria ^{[1
]}

Antonio Gabaldon, Jose ^{[1
]}

Nunez-Delicado, Estrella ^{[1
]}

机构：

[1] Univ Catolica Murcia UCAM, Hlth Sci Dept, Mol Recognit & Encapsulat Res Grp REM, Campus Los Jeronimos 135, Murcia 30107, Spain

[2] Univ Catolica Murcia UCAM, Comp Engn Dept, Struct Bioinformat & High Performance Comp Grp BI, Campus Los Jeronimos 135, Murcia 30107, Spain

来源：

MOLECULES | 2020年 / 25卷 / 21期

关键词：

linalool; HP-β -cyclodextrins; solid complexes; chemical characterization; molecular modeling; ESSENTIAL OILS; ANTIOXIDANT; ANTIBACTERIAL; (-)-LINALOOL; OPTIMIZATION; SALMONELLA; SOLUBILITY; FOODS;

D O I：

10.3390/molecules25215069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of the present study is to obtain linalool- cyclodextrin (CDs) solid complexes for possible applications in the food industry. For this purpose, a detailed study of linalool complexation was carried out at different pH values, to optimize the type of CDs and reaction medium that support the highest quantity of encapsulated linalool. Once demonstrated the ability of hydroxypropyl-beta-cyclodextrin (HP-beta-CDs), to form inclusion complexes with linalool (K-C = 921 +/- 21 L mol(-1)) and given their greater complexation efficacy (6.788) at neutral pH, HP-beta-CDs were selected to produce solid inclusion complexes by using two different energy sources, ultrasounds and microwave irradiation, subsequently spraying the solutions obtained in the Spray Dryer. To provide scientific solidity to the experimental results, the complexes obtained were characterized by using different instrumental techniques in order to confirm the inclusion of linalool in the HP-beta-CDs hydrophobic cavity. The linalool solid complexes obtained were characterized by using H-1 nuclear magnetic resonance (H-1-NMR) and 2D nuclear magnetic resonance (ROSEY), differential scanning calorimetry, thermogravimetry and Fourier transform infrared spectrometry. Moreover, the structure of the complex obtained were also characterized by molecular modeling.

引用

页数：18