Total neoadjuvant therapy in locally advanced rectal cancer: Role of systemic chemotherapy

被引：31

作者：

Yoo, Ri Na ^{[1
]}

Kim, Hyung Jin ^{[1
]}

机构：

[1] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Surg,Div Colorectal Surg, 93-6 Ji Dong, Suwon 442723, Gyeonggi Do, South Korea

来源：

ANNALS OF GASTROENTEROLOGICAL SURGERY | 2019年 / 3卷 / 04期

关键词：

chemoradiation; chemotherapy; neoadjuvant therapy; organ preservation; rectal cancer; TOTAL MESORECTAL EXCISION; POSTOPERATIVE ADJUVANT CHEMOTHERAPY; PATHOLOGICAL COMPLETE RESPONSE; MEDIAN FOLLOW-UP; PHASE-III TRIAL; PREOPERATIVE RADIOTHERAPY; RADIATION-THERAPY; IMPROVED SURVIVAL; TUMOR RESPONSE; CONSOLIDATION CHEMOTHERAPY;

D O I：

10.1002/ags3.12253

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

For the past several decades, disease-related outcomes, particularly local recurrence rate, in patients with locally advanced rectal cancer have significantly improved as a result of advancement of surgical technique and implementation of neoadjuvant chemoradiation. However, distant metastasis remains unresolved, being a significant cause of cancer death. To focus on micrometastases early in the course of multimodal treatment, delivering systemic chemotherapy in the neoadjuvant setting is emerging. Also, driven by patient demand and interest in preserving quality of life, upfront chemotherapy prior to surgery serves as a strategy for organ preservation in the management of rectal cancer. Herein, currently available literature on different methods and strategies of the multimodal approach is critically appraised.

引用

页码：356 / 367

页数：12

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