Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis

被引:16
作者
Ewer, AK [1 ]
机构
[1] Birmingham Womens Hosp, Neonatal Unit, Birmingham B15 2TG, W Midlands, England
[2] Univ Birmingham, Birmingham, W Midlands, England
关键词
inflammatory mediators; necrotizing enterocolitis; platelet-activating factor; preterm infants;
D O I
10.1080/08035250260095717
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal illness that affects predominantly preterm infants. Treatment options are limited and NEC remains a significant cause of morbidity and mortality. The precise aetiology of NEC remains unclear but evidence strongly suggests that the cause is multifactorial and there are four main aetiological factors: prematurity, hypoxia. enteral feeding and bacterial colonization. The presence of similar intestinal lesions, regardless of aetiological trigger, strongly implicates a final common pathway in the pathogenesis. There is now a substantial body of evidence to indicate that endogenous inflammatory mediators, particularly platelet-activating factor (PAF), play a vital role in this final pathway, Conclusion: The use of agents that antagonize PAF may provide therapeutic options in the management of NEC.
引用
收藏
页码:2 / 5
页数:4
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