Gold opens mitochondrial pathways to apoptosis

被引：23

作者：

McKeage, MJ ^{[1
]}

机构：

[1] Univ Auckland, Div Pharmacol & Clin Pharmacol, Auckland 1, New Zealand

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2002年 / 136卷 / 08期

关键词：

apoptosis; auranofin; bcl-2; cancer chemotherapy; cytochrome c; gold complexes; mitochondria; mitochondrial permeability transition; thioredoxin reductase;

D O I：

10.1038/sj.bjp.0704822

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：1081 / 1082

页数：2

共 10 条

[1] Mitochondrion as a novel target of anticancer chemotherapy [J].

Costantini, P ;

Jacotot, E ;

Decaudin, D ;

Kroemer, G .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (13) :1042-1053

[2] Mitochondria as the central control point of apoptosis [J].

Desagher, S ;

Martinou, JC .

TRENDS IN CELL BIOLOGY, 2000, 10 (09) :369-377

[3] Mitochondria: execution central [J].

Gottlieb, RA .

FEBS LETTERS, 2000, 482 (1-2) :6-12

[4] Human placenta thioredoxin reductase - Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds [J].

Gromer, S ;

Arscott, LD ;

Williams, CH ;

Schirmer, RH ;

Becker, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20096-20101

[5]

MCKEAGE MJ, 2002, IN PRESS COORD CHEM

[6]

MIRABELLI CK, 1985, CANCER RES, V45, P32

[7] Mitochondria as target for antiischemic drugs [J].

Morin, D ;

Hauet, T ;

Spedding, M ;

Tillement, JP .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 49 (1-2) :151-174

[8] Purification of mitochondrial thioredoxin reductase and its involvement in the redox regulation of membrane permeability [J].

Rigobello, MP ;

Callegaro, MT ;

Barzon, E ;

Benetti, M ;

Bindoli, A .

FREE RADICAL BIOLOGY AND MEDICINE, 1998, 24 (02) :370-376

[9] Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative [J].

Rigobello, MP ;

Scutari, G ;

Boscolo, R ;

Bindoli, A .

BRITISH JOURNAL OF PHARMACOLOGY, 2002, 136 (08) :1162-1168

[10] Phase I clinical and pharmacokinetic study of Bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma [J].

Waters, JS ;

Webb, A ;

Cunningham, D ;

Clarke, PA ;

Raynaud, F ;

di Stefano, F ;

Cotter, FE .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (09) :1812-1823

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