Mouse Models Address Key Concerns Regarding Autophagy Inhibition in Cancer Therapy

被引：21

作者：

Amaravadi, Ravi ^{[1
,2
]}

Debnath, Jayanta ^{[3
,4
]}

机构：

[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

CANCER DISCOVERY | 2014年 / 4卷 / 08期

关键词：

P53; PROGRESSION; GROWTH; TUMORS;

D O I：

10.1158/2159-8290.CD-14-0618

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With multiple clinical trials under way targeting autophagy against cancer, Yang and colleagues and Karsli-Uzunbas and colleagues address important concerns regarding autophagy inhibition in patients with cancer, using genetically engineered mouse models that more accurately represent the tumor biology found in human patients with pancreatic and lung cancers. (C) 2014 AACR.

引用

页码：873 / 875

页数：3

共 10 条

[1] Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis [J].

Guo, Jessie Yanxiang ;

Karsli-Uzunbas, Gizem ;

Mathew, Robin ;

Aisner, Seena C. ;

Kamphorst, Jurre J. ;

Strohecker, Anne M. ;

Chen, Guanghua ;

Price, Sandy ;

Lu, Wenyun ;

Teng, Xin ;

Snyder, Eric ;

Santanam, Urmila ;

DiPaola, Robert S. ;

Jacks, Tyler ;

Rabinowitz, Joshua D. ;

White, Eileen .

GENES & DEVELOPMENT, 2013, 27 (13) :1447-1461

[2] Autophagy, p53, and Pancreatic Cancer [J].

Iacobuzio-Donahue, Christine A. ;

Herman, Joseph M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (14) :1352-1353

[3] Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance [J].

Karsli-Uzunbas, Gizem ;

Guo, Jessie Yanxiang ;

Price, Sandy ;

Teng, Xin ;

Laddha, Saurabh V. ;

Khor, Sinan ;

Kalaany, Nada Y. ;

Jacks, Tyler ;

Chan, Chang S. ;

Rabinowitz, Joshua D. ;

White, Eileen .

CANCER DISCOVERY, 2014, 4 (08) :914-927

[4] The dynamic nature of autophagy in cancer [J].

Kimmelman, Alec C. .

GENES & DEVELOPMENT, 2011, 25 (19) :1999-2010

[5]

Rangwala R., 2014, Autophagy, V10

[6] A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme [J].

Rosenfeld, Myrna R. ;

Ye, Xiaobu ;

Supko, Jeffrey G. ;

Desideri, Serena ;

Grossman, Stuart A. ;

Brem, Steven ;

Mikkelson, Tom ;

Wang, Daniel ;

Chang, Yunyoung C. ;

Hu, Janice ;

McAfee, Quentin ;

Fisher, Joy ;

Troxel, Andrea ;

Piao, Shengfu ;

Heitjan, Daniel F. ;

Tan, Kay See ;

Pontiggia, Laura ;

O'Dwyer, Peter J. ;

Davis, Lisa E. ;

Amaravadi, Ravi K. .

AUTOPHAGY, 2014, 10 (08) :1359-1368

[7] p53 status determines the role of autophagy in pancreatic tumour development [J].

Rosenfeldt, Mathias T. ;

O'Prey, Jim ;

Morton, Jennifer P. ;

Nixon, Colin ;

MacKay, Gillian ;

Mrowinska, Agata ;

Au, Amy ;

Rai, Taranjit Singh ;

Zheng, Liang ;

Ridgway, Rachel ;

Adams, Peter D. ;

Anderson, Kurt I. ;

Gottlieb, Eyal ;

Sansom, Owen J. ;

Ryan, Kevin M. .

NATURE, 2013, 504 (7479) :296-+

[8] Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors [J].

Strohecker, Anne M. ;

Guo, Jessie Yanxiang ;

Karsli-Uzunbas, Gizem ;

Price, Sandy M. ;

Chen, Guanghua Jim ;

Mathew, Robin ;

McMahon, Martin ;

White, Eileen .

CANCER DISCOVERY, 2013, 3 (11) :1272-1285

[9] Combined autophagy and proteasome inhibition A phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma [J].

Vogl, Dan T. ;

Stadtmauer, Edward A. ;

Tan, Kay See ;

Heitjan, Daniel F. ;

Davis, Lisa E. ;

Pontiggia, Laura ;

Rangwala, Reshma ;

Piao, Shengfu ;

Chang, Yunyoung C. ;

Scott, Emma C. ;

Paul, Thomas M. ;

Nichols, Charles W. ;

Porter, David L. ;

Kaplan, Janeen ;

Mallon, Gayle ;

Bradner, James E. ;

Amaravadi, Ravi K. .

AUTOPHAGY, 2014, 10 (08) :1380-1390

[10] Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations [J].

Yang, Annan ;

Rajeshkumar, N. V. ;

Wang, Xiaoxu ;

Yabuuchi, Shinichi ;

Alexander, Brian M. ;

Chu, Gerald C. ;

Von Hoff, Daniel D. ;

Maitra, Anirban ;

Kimmelman, Alec C. .

CANCER DISCOVERY, 2014, 4 (08) :905-913

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