Mouse Models Address Key Concerns Regarding Autophagy Inhibition in Cancer Therapy

被引：21

作者：

Amaravadi, Ravi ^{[1
,2
]}

Debnath, Jayanta ^{[3
,4
]}

机构：

[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

CANCER DISCOVERY | 2014年 / 4卷 / 08期

关键词：

P53; PROGRESSION; GROWTH; TUMORS;

D O I：

10.1158/2159-8290.CD-14-0618

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With multiple clinical trials under way targeting autophagy against cancer, Yang and colleagues and Karsli-Uzunbas and colleagues address important concerns regarding autophagy inhibition in patients with cancer, using genetically engineered mouse models that more accurately represent the tumor biology found in human patients with pancreatic and lung cancers. (C) 2014 AACR.

引用

页码：873 / 875

页数：3

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