Topical tamoxifen in the therapy of cutaneous leishmaniasis

被引：30

作者：

Trinconi, Cristiana T. ^{[1
]}

Reimao, Juliana Q. ^{[1
,2
]}

Bonano, Vivian, I ^{[1
]}

Espada, Caroline R. ^{[1
]}

Miguel, Danilo C. ^{[1
,3
]}

Yokoyama-Yasunaka, Jenicer K. U. ^{[1
]}

Uliana, Silvia R. B. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Av Prof Lineu Prestes 1374, BR-05508000 Sao Paulo, Brazil

[2] Fac Med Jundiai, Dept Morfol & Patol Basica, Jundiai, SP, Brazil

[3] Univ Estadual Campinas, Inst Biol, Dept Biol Anim, Campinas, SP, Brazil

来源：

PARASITOLOGY | 2018年 / 145卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

Topical treatment; tamoxifen; Leishmania amazonensis; combination therapy; luciferase; CONTROLLED CLINICAL-TRIAL; AMPHOTERICIN-B; IN-VITRO; MILTEFOSINE; EFFICACY; AMAZONENSIS; BRAZILIENSIS; AFGHANISTAN; INFECTIONS; GUYANENSIS;

D O I：

10.1017/S0031182017000130

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial combinations in an experimental model of cutaneous leishmaniasis. BALB/c mice infected with a luciferase expressing line of Lrishmania amazonerisis were treated with topical tamoxifen in two different formulations (cthanol or oil-free cream) as monotherapy or in co-administration with pentavalent antimonial. Treatment efficacy was evaluated by lesion size and parasite burden, quantified through luminescence, at the end of treatment and 4 weeks later. Topical tamoxifen, formulated in ethanol or as a cream, was shown to be effective. The interaction between tamoxifen and pentavalent antimonial was additive in vitro. Treatment with combined schemes containing tamoxifen and pentavalent antimonial was effective in reducing lesion size and parasite burden. Co-administration of tamoxifen and pentavalent antimonial was superior to monotherapy with antimonial.

引用

页码：490 / 496

页数：7

共 28 条

[1] Chemotherapy in the treatment and control of leishmaniasis [J].