Capillary Dropout at the Retinal Nerve Fiber Layer Defect in Glaucoma: An Optical Coherence Tomography Angiography Study

被引：31
作者：
Ichiyama, Yusuke [1 ]
Minamikawa, Takayuki [1 ]
Niwa, Yuichi [1 ]
Ohji, Masahito [1 ]
机构：
[1] Shiga Univ Med Sci, Dept Ophthalmol, Otsu, Shiga 5202192, Japan
来源：
JOURNAL OF GLAUCOMA | 2017年 / 26卷 / 04期
关键词：
glaucoma; retinal nerve fiber layer; optical coherence tomography angiography; capillary; microvascular network; radial peripapillary capillaries; OPEN-ANGLE GLAUCOMA; NORMAL-PRESSURE GLAUCOMA; DISC PERFUSION; BLOOD-FLOW; HEAD;
D O I：
10.1097/IJG.0000000000000540
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose:To investigate the microvasculature changes of retinal nerve fiber layer (RNFL) defects in glaucoma.Design:The study design is a case report.Patients and Methods:Four glaucomatous eyes were included in this observational cross-sectional study. The microvasculature changes of RNFL defects were examined using optical coherence tomography (OCT) angiography.Results:Three eyes had apparent wedge-shaped capillary dropout on OCT angiography. In the fourth eye, detection of wedge-shaped capillary loss was difficult because of overall capillary drop out due to advanced glaucoma. Capillary dropout detection by OCT angiography was correlated with visual field loss and RNFL defect detection by regular OCT. Compared with regular OCT used to obtain retinal thickness maps, OCT angiography is often better at visualizing the borders of lesions in the RNFL.Conclusions:OCT angiography can detect capillary dropout in RNFL defects in glaucomatous eyes, and therefore could be a useful glaucoma examination tool.
引用
收藏
页码：E142 / E145
页数：4
相关论文
共 14 条
[1]   Pathogenetic aspects of the glaucomatous optic neuropathy: fluorescein angiographic findings in patients with primary open angle glaucoma [J].
Arend, O ;
Plange, N ;
Sponsel, WE ;
Remky, A .
BRAIN RESEARCH BULLETIN, 2004, 62 (06) :517-524
[2]   Evaluation of optic nerve head and peripapillary retinal blood flow in glaucoma patients, ocular hypertensives, and normal subjects [J].
Hafez, AS ;
Bizzarro, RLG ;
Lesk, MR .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2003, 136 (06) :1022-1031
[3]   OPTIC-NERVE HEAD BLOOD-FLOW USING A LASER-DOPPLER VELOCIMETER AND HEMORHEOLOGY IN PRIMARY OPEN-ANGLE GLAUCOMA AND NORMAL-PRESSURE GLAUCOMA [J].
HAMARD, P ;
HAMARD, H ;
DUFAUX, J ;
QUESNOT, S .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1994, 78 (06) :449-453
[4]   Comparison of colour Doppler imaging and retinal scanning laser fluorescein angiography in healthy volunteers and normal pressure glaucoma patients [J].
Huber, K ;
Plange, N ;
Remky, A ;
Arend, O .
ACTA OPHTHALMOLOGICA SCANDINAVICA, 2004, 82 (04) :426-431
[5]   Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma [J].
Jia, Yali ;
Wei, Eric ;
Wang, Xiaogang ;
Zhang, Xinbo ;
Morrison, John C. ;
Parikh, Mansi ;
Lombardi, Lori H. ;
Gattey, Devin M. ;
Armour, Rebecca L. ;
Edmunds, Beth ;
Kraus, Martin F. ;
Fujimoto, James G. ;
Huang, David .
OPHTHALMOLOGY, 2014, 121 (07) :1322-1332
[6]   Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma [J].
Liu, Liang ;
Jia, Yali ;
Takusagawa, Hana L. ;
Pechauer, Alex D. ;
Edmunds, Beth ;
Lombardi, Lorinna ;
Davis, Ellen ;
Morrison, John C. ;
Huang, David .
JAMA OPHTHALMOLOGY, 2015, 133 (09) :1045-1052
[7]  
Michelson G, 1996, J GLAUCOMA, V5, P91
[8]   Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects [J].
Piltz-Seymour, IR ;
Grunwald, JE ;
Hariprasad, SM ;
DuPont, J .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2001, 132 (01) :63-69
[9]  
TALUSAN E, 1977, ARCH OPHTHALMOL-CHIC, V95, P2166
[10]   Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study [J].
Wang, Xiaolei ;
Jiang, Chunhui ;
Ko, Tony ;
Kong, Xiangmei ;
Yu, Xiaobo ;
Min, Wang ;
Shi, Guohua ;
Sun, Xinghuai .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2015, 253 (09) :1557-1564
12