Predictive factors for sentinel lymph nodes and non-sentinel lymph nodes metastatic involvement: a database study of 1,041 melanoma patients

被引：18

作者：

Kibrite, Antoine ^{[1
]}

Milot, Helene ^{[2
]}

Douville, Pierre ^{[3
]}

Gagne, Eric J. ^{[3
]}

Labonte, Sebastien ^{[3
]}

Friede, Juan ^{[4
]}

Morin, Francis ^{[4
]}

Ouellet, Jean-Francois ^{[1
]}

Claveau, Joel ^{[5
]}

机构：

[1] CHU Quebec, Dept Surg, Quebec City, PQ G1R 2J6, Canada

[2] Hop Le Royer, Dept Gen Surg, Quebec City, PQ, Canada

[3] CHU Quebec, Dept Med Biol, Quebec City, PQ, Canada

[4] CHU Quebec, Dept Med Imaging, Quebec City, PQ, Canada

[5] CHU Quebec, Dept Dermatol, Quebec City, PQ, Canada

来源：

AMERICAN JOURNAL OF SURGERY | 2016年 / 211卷 / 01期

关键词：

Melanoma; Sentinel lymph node; Breslow thickness; Mitotic rate; Lymphovascular invasion; Lymphadenectomy; PRIMARY CUTANEOUS MELANOMA; TUMOR MITOTIC RATE; MALIGNANT-MELANOMA; NODAL OBSERVATION; BIOPSY; MULTICENTER; CRITERIA;

D O I：

10.1016/j.amjsurg.2015.05.016

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: Sentinel lymph node (SLN) biopsy may identify patients who may need completion lymphadenectomy and adjuvant therapy. METHODS: Univariate and multivariate analysis were conducted for SLN status in a prospective cohort of 1,041 patients. A biopsy was recommended for melanoma greater than or equal to 1 mm thick or greater than or equal to .75 mm with poor prognostic features. RESULTS: For sentinel node status, mitotic rate is very significant in univariate analysis. In multivariate analysis, Breslow, lymphovascular invasion, and primary site were significant. Breslow thickness greater than or equal to 2 mm and SLN with macroscopic burden greater than or equal to 2 mm are the only statistically significant variables predicting the non-SLN status in multivariate analysis. CONCLUSIONS: The data confirm the importance of Breslow, lymphovascular invasion, and body site for SLN status. The cutoff of 2 mm for tumor load in SLN appears to be a simple technique to find the high-risk patients with further lymph node disease. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：89 / 94

页数：6

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