GRP78 Secreted by Colon Cancer Cells Facilitates Cell Proliferation via PI3K/Akt Signaling

被引：42

作者：

Fu, Rong ^{[1
]}

Yang, Peng ^{[1
]}

Wu, Hai-Li ^{[1
]}

Li, Zong-Wei ^{[1
]}

Li, Zhuo-Yu ^{[1
,2
]}

机构：

[1] Shaxi Univ, Natl Minist Educ, Key Lab Chem Biol & Mol Engn, Inst Biotechnol, Taiyuan, Peoples R China

[2] Zhejiang Chinese Med Univ, Coll Lif Sci, Hangzhou, Zhejiang, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 17期

基金：

山西省青年科学基金; 中国国家自然科学基金;

关键词：

autocrine; colon cancer; glucose regulated protein 78; proliferation; UNFOLDED PROTEIN RESPONSE; COOH-TERMINAL DOMAIN; COLORECTAL-CANCER; SURFACE GRP78; ACTIVATION; PATHWAYS; LIGATION; APOPTOSIS; AKT;

D O I：

10.7314/APJCP.2014.15.17.7245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glucose regulated protein 78 (GRP78) is usually recognized as a chaperone in the endoplasmic reticulum. However, increasing evidence indicates that GRP78 can be translocated to the cell surface, acting as a signaling receptor for a variety of ligands. Since little is known about the secretion of GRP78 and its role in the progression of colon cancer we here focused on GRP78 from colon cancer cells, and purified GRP78 protein mimicking the secreted GRP78 was able to utilize cell surface GRP78 as its receptor, activating downstream PI3K/Akt and Wnt/beta-catenin signaling and promote colon cancer cell proliferation. Our study revealed a new mode of action of autocrine GRP78 in cancer progression: secreted GRP78 binds to cell surface GRP78 as its receptor and activates intracellular proliferation signaling.

引用

页码：7245 / 7249

页数：5

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