The potential to predict the course of childhood asthma

被引：15

作者：

Belsky, Daniel W. ^{[1
]}

Sears, Malcolm R. ^{[2
]}

机构：

[1] Duke Univ, Ctr Study Aging & Human Dev, Med Ctr, Durham, NC 27708 USA

[2] McMaster Univ, AstraZeneca Chair Resp Epidemiol, Firestone Inst Resp Hlth, St Josephs Healthcare, Hamilton, ON L8N 4A6, Canada

来源：

EXPERT REVIEW OF RESPIRATORY MEDICINE | 2014年 / 8卷 / 02期

关键词：

asthma; atopy; birth cohort; children; genetic risk score; longitudinal studies; persistence; severity; GENOME-WIDE ASSOCIATION; EXHALED NITRIC-OXIDE; PRESCHOOL-CHILDREN; GENETIC RISK; BRONCHIAL HYPERRESPONSIVENESS; WHEEZING ILLNESS; NATURAL-HISTORY; AGE; DISEASE; ONSET;

D O I：

10.1586/17476348.2014.879826

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Many children experience pre-school or early childhood wheezing. In a significant proportion symptoms disappear as the child grows, but others have persistent and troublesome asthma which can be life-long. Tools to predict course of disease in young children are a priority for families and clinicians. This review summarizes evidence from several longitudinal population-based birth-cohort studies that have identified risk factors for persistence and remission of childhood asthma. These factors include clinical characteristics, environmental and other exposures, familial factors, biomarkers of allergic inflammation, measurements of lung function and airway responsiveness, and genetic variants. This review also introduces the concept of polygenic risk and genetic risk scores, and describes results from a recent study that suggests promise for the use of genetic information in predicting the course of childhood asthma. We conclude with a discussion of implications and future directions.

引用

页码：137 / 141

页数：5

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