Klymollins T-X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle

被引：15

作者：

Chang, Fang-Yu ^{[1
]}

Hsu, Fang-Jung ^{[1
]}

Tai, Chi-Jen ^{[1
]}

Wei, Wen-Chi ^{[2
]}

Yang, Ning-Sun ^{[2
,3
,4
]}

Sheu, Jyh-Horng ^{[1
,5
,6
,7
,8
,9
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan

[3] Natl Taiwan Univ, Inst Biotechnol, Taipei 106, Taiwan

[4] Natl Cent Univ, Dept Life Sci, Taoyuan 320, Taiwan

[5] Natl Sun Yat Sen Univ, Div Marine Biotechnol, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[6] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan

[7] Acad Sinica, Kaohsiung 804, Taiwan

[8] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[9] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

MARINE DRUGS | 2014年 / 12卷 / 05期

关键词：

soft coral; Klyxum molle; eunicellin-based diterpenoids; klymollins; cytotoxic activity; anti-inflammatory activity; A-H; DISCOVERY;

D O I：

10.3390/md12053060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.

引用

页码：3060 / 3071

页数：12

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