High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone

被引:4
作者
Basic-Kinda, Sandra [1 ]
Karlak, Ivan [3 ]
Durakovic, Nadira [1 ,4 ]
Lubina, Zvonimir, I [5 ]
Radman, Ivo Livaja [1 ]
Dotlic, Snjezana [2 ]
Peric, Zinaida [1 ,4 ]
Hude, Ida [1 ]
Aurer, Igor [1 ,4 ]
机构
[1] Univ Hosp Ctr Zagreb, Div Hematol, Dept Internal Med, Kispaticeva 12, Zagreb 10000, Croatia
[2] Univ Hosp Ctr Zagreb, Dept Pathol, Zagreb, Croatia
[3] Univ Zagreb, Dept Traumatol, Univ Hosp Ctr Sisters Mercy, Zagreb, Croatia
[4] Univ Zagreb, Sch Med, Zagreb, Croatia
[5] Northampton Gen Hosp, Dept Radiol, Northampton, England
关键词
Hodgkin lymphoma; eBEACOPP; avascular necrosis of femoral head; steroids; methylprednisolone; HIGH-RISK; AVASCULAR NECROSIS; INTERGROUP TRIAL; PROGNOSTIC SCORE; STAGE-III; DISEASE; STANDARD; CORTICOSTEROIDS; OSTEONECROSIS; CHEMOTHERAPY;
D O I
10.1111/imj.13653
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Escalated BEACOPP (eBEACOPP) is an effective but fairly toxic regimen for the treatment of Hodgkin lymphoma (HL). Avascular necrosis (AVN) of femoral head was previously reported to increase in patients treated with eBEACOPP, but so far, no systematic analysis of its frequency has been published. Aims: To analyse the frequency and identify possible risk factors for AVN development in patients treated with eBEACOPP. Methods: We identified 26 patients treated with eBEACOPP for newly diagnosed high-risk advanced-stage HL, 25 of whom were alive at the time of study. All patients were invited to participate in a cross-sectional study; 17 patients responded and were evaluated by magnetic resonance imaging and orthopaedic examination. Results: Six patients (35.3%) were diagnosed with AVN after receiving eBEACOPP treatment. AVN was not correlated with age, gender, number of received eBEACOPP cycles, irradiation therapy or cumulative dose of steroids administered. There were significantly more cases of AVN in patients receiving methylprednisolone than prednisone (P = 0.01). Conclusion: The use of methylprednisolone was shown to be a risk factor for the development of AVN in patients treated with eBEACOPP and should not be the corticosteroid of choice in the treatment of patients with HL.
引用
收藏
页码:523 / +
页数:7
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