Studies on coumestrol/β-cyclodextrin characterization

被引：41

作者：

Franco, Camila ^{[1
]}

Schwingel, Liege ^{[1
]}

Lula, Ivana ^{[2
]}

Sinisterra, Ruben D. ^{[2
]}

Koester, Leticia Scherer ^{[1
]}

Bassani, Valquiria Linck ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Fac Farm, Programa Posgrad Ciencias Farmaceut, BR-90610000 Porto Alegre, RS, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 369卷 / 1-2期

关键词：

Coumestrol; Cyclodextrin; Complexation; Modeling; BETA-CYCLODEXTRIN; PHYTOESTROGEN COUMESTROL; COMPLEXES;

D O I：

10.1016/j.ijpharm.2008.10.026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Coumestrol is an estrogenic and antioxidant agent, characterized by its low solubility in aqueous and lipophilic media, once in the aglicone form. In order to improve its solubility in water, coumestrol was associated with beta-cyclodextrin in aqueous media followed by freeze-drying and characterized by SEM, H-1 NMR and molecular modeling. The analysis proved the existence of an inclusion complex, with higher probability of inclusion of the coumestrol B-ring into the wider rim of the beta-cyclodextrin molecule. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：5 / 11

页数：7

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