Peptide array functionalization via the Ugi four-component reaction

被引：16

作者：

Ridder, B. ^{[1
,2
]}

Mattes, D. S. ^{[1
,3
]}

Nesterov-Mueller, A. ^{[1
]}

Breitling, F. ^{[1
]}

Meier, M. A. R. ^{[2
]}

机构：

[1] KIT, IMT, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

[2] KIT, IOC, Str Forum 7, D-76131 Karlsruhe, Germany

[3] KIT, IOC, Fritz Haber Weg 6, D-76131 Karlsruhe, Germany

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 40期

关键词：

MULTICOMPONENT REACTIONS; COMBINATORIAL SYNTHESIS; SOLID-PHASE; CYCLIC-PEPTIDES; SIDE-CHAINS; AMINO; CONDENSATION; PEPTIDOMIMETICS; ISOCYANIDES; MACROARRAYS;

D O I：

10.1039/c7cc01945a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated.

引用

页码：5553 / 5556

页数：4

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