Synthesis, Characterization and Fluorescence Properties of Zn(II) and Cu(II) Complexes: DNA Binding Study of Zn(II) Complex

被引：5
|
作者：
Lavaee, Parirokh [1 ]
Eshtiagh-Hosseini, Hossein [1 ]
Housaindokht, Mohammad Reza [1 ]
Mague, Joel T. [2 ]
Esmaeili, Abbas Ali [1 ]
Abnous, Khalil [3 ]
机构：
[1] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad 917751436, Iran
[2] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA
[3] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran
来源：
JOURNAL OF FLUORESCENCE | 2016年 / 26卷 / 01期
关键词：
Copper; Zinc; Schiff base; Interaction; DNA; Fluorescence; SCHIFF-BASE LIGAND; COPPER(II) COMPLEX; METAL-COMPLEXES; CANCER-CELLS; NEUTRAL RED; PROBE; DERIVATIVES; DYE;
D O I：
10.1007/s10895-015-1719-6
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Zinc(II) and copper(II) complexes containing Schiff base, 2- methoxy-6((E)-(phenylimino) methyl) phenol ligand (HL) were synthesized and characterized by elemental analysis, IR, NMR, and single crystal X-ray diffraction technique. The fluorescence properties and quantum yield of zinc complex were studied. Our data showed that Zn complex could bind to DNA grooves with K-b = 10(4) M-1. Moreover, Zn complex could successfully be used in staining of DNA following agarose gel electrophoresis. MTT assay showed that Zn complex was not cytotoxic in MCF-7 cell line. Here, we introduce a newly synthesized fluorescence probe that can be used for single and double stranded DNA detection in both solution and agarose gels.
引用
收藏
页码：333 / 344
页数：12
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