Synthesis, Characterization and Fluorescence Properties of Zn(II) and Cu(II) Complexes: DNA Binding Study of Zn(II) Complex

被引：5

作者：

Lavaee, Parirokh ^{[1
]}

Eshtiagh-Hosseini, Hossein ^{[1
]}

Housaindokht, Mohammad Reza ^{[1
]}

Mague, Joel T. ^{[2
]}

Esmaeili, Abbas Ali ^{[1
]}

Abnous, Khalil ^{[3
]}

机构：

[1] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad 917751436, Iran

[2] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

[3] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran

来源：

JOURNAL OF FLUORESCENCE | 2016年 / 26卷 / 01期

关键词：

Copper; Zinc; Schiff base; Interaction; DNA; Fluorescence; SCHIFF-BASE LIGAND; COPPER(II) COMPLEX; METAL-COMPLEXES; CANCER-CELLS; NEUTRAL RED; PROBE; DERIVATIVES; DYE;

D O I：

10.1007/s10895-015-1719-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Zinc(II) and copper(II) complexes containing Schiff base, 2- methoxy-6((E)-(phenylimino) methyl) phenol ligand (HL) were synthesized and characterized by elemental analysis, IR, NMR, and single crystal X-ray diffraction technique. The fluorescence properties and quantum yield of zinc complex were studied. Our data showed that Zn complex could bind to DNA grooves with K-b = 10(4) M-1. Moreover, Zn complex could successfully be used in staining of DNA following agarose gel electrophoresis. MTT assay showed that Zn complex was not cytotoxic in MCF-7 cell line. Here, we introduce a newly synthesized fluorescence probe that can be used for single and double stranded DNA detection in both solution and agarose gels.

引用

页码：333 / 344

页数：12

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