Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer

被引：95

作者：

Fazi, Francesco ^{[1
]}

Fatica, Alessandro ^{[2
]}

机构：

[1] Sapienza Univ Rome, Dept Anat Histol Forens & Orthoped Sci, Sect Histol & Med Embryol, Lab Ist Pasteur Italia Fdn Cenci Bolognetti, Rome, Italy

[2] Sapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, Rome, Italy

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2019年 / 7卷

关键词：

epitranscriptomics; m6A; RNA modifications; non-coding RNAs; microRNAs; lncRNAs; cell reprogramming; ESC development; COMPETING ENDOGENOUS RNA; MESSENGER-RNA; NUCLEAR-RNA; LNCRNA MALAT1; METHYLATION; METHYLTRANSFERASE; EXPRESSION; METTL16; PROTEIN; N6-METHYLADENOSINE;

D O I：

10.3389/fcell.2019.00116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNA chemical modifications in coding and non-coding RNAs have been known for decades. They are generally installed by specific enzymes and, in some cases, can be read and erased by other specific proteins. The impact of RNA chemical modifications on gene expression regulation and the reversible nature of some of these modifications led to the birth of the word epitranscriptomics, in analogy with the changes that occur on DNA and histones. Among more than 100 different modifications identified so far, most of the epitranscriptomics studies focused on the N-6-methyladenosine (m(6)A), which is the more abundant internal modification in protein coding RNAs. m(6)A can control several pathways of gene expression, including spicing, export, stability, and translation. In this review, we describe the interplay between m(6)A and non-coding RNAs, in particular microRNAs and lncRNAs, with examples of its role in gene expression regulation. Finally, we discuss its relevance in cell development and disease.

引用

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