Synthesis of 3-alkylquinoxalin-2(1H)-ones via Grignard reaction

被引：9

作者：

Kalinin, A. A. ^{[1
]}

Mamedov, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, AE Arbuzov Organ & Phys Chem Inst, Kazan Res Ctr, Kazan 420088, Tatarstan, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 45卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

RECEPTOR ANTAGONISTS; N-OXIDES; DERIVATIVES;

D O I：

10.1134/S1070428009070185

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-step procedure has been developed for the synthesis of 3-alkylquinoxalin-2(1H)-ones from o-phenylenediamine and ethyl 2-oxoalkanoates prepared by the Grignard reaction of diethyl oxalate with alkyl bromides. Analogous reaction with alpha,omega-dibromoalkanes instead of alkyl bromides leads to the formation of 3,3'-(alkane-alpha,omega-diyl)di[quinoxalin-2(1H)-ones].

引用

页码：1098 / 1101

页数：4

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