The Tumor Microenvironment of Primitive and Metastatic Breast Cancer: Implications for Novel Therapeutic Strategies

被引：31

作者：

Zarrilli, Giovanni ^{[1
]}

Businello, Gianluca ^{[1
]}

Dieci, Maria Vittoria ^{[2
,3
]}

Paccagnella, Silvia ^{[1
]}

Carraro, Valentina ^{[1
]}

Cappellesso, Rocco ^{[1
]}

Miglietta, Federica ^{[3
]}

Griguolo, Gaia ^{[2
,3
]}

Guarneri, Valentina ^{[2
,3
]}

Lo Mele, Marcello ^{[4
]}

Fassan, Matteo ^{[1
]}

机构：

[1] Univ Padua, Dept Med DIMED, Surg Pathol & Cytopathol Unit, I-35121 Padua, Italy

[2] IRCCS, Med Oncol 2, Ist Oncol Veneto IOV, I-35128 Padua, Italy

[3] Univ Padua, Dept Surg Oncol & Gastroenterol DISCoG, I-35121 Padua, Italy

[4] Univ Hosp Padua, Surg Pathol Unit, I-35121 Padua, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 21期

关键词：

tumor microenvironment; stroma; tumor infiltrating lymphocytes; breast cancer; REGULATORY T-CELLS; HIPPO TRANSDUCER TAZ; INFILTRATING LYMPHOCYTES; PREDICTIVE-VALUE; EXPRESSION; GROWTH; SUBTYPES; MACROPHAGES; PATHWAY; YAP;

D O I：

10.3390/ijms21218102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer evolves thanks to a dense and close interaction with the surrounding tumor microenvironment (TME). Fibroblasts, leukocytes, blood and lymphatic endothelial cells and extracellular matrix are the constituents of this entity, and they synergistically play a pivotal role in all of the stages of breast cancer development, from its onset to its metastatic spread. Moreover, it has been widely demonstrated that variations to the TME can correspond to prognosis variations. Breast cancer not only modulates the transformation of the environment within the mammary gland, but the same process is observed in metastases as well. In this minireview, we describe the features of TME within the primitive breast cancer, throughout its evolution and spread into the main metastatic sites.

引用

页码：1 / 23

页数：23

共 162 条

[1] Basal-Like and Triple-Negative Breast Cancers Searching for Positives Among Many Negatives [J].

Alluri, Prasanna ;

Newman, Lisa A. .

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2014, 23 (03) :567-+

[2] The role and function of cadherins in the mammary gland [J].

Andrews, Jennifer L. ;

Kim, Alvin C. ;

Hens, Julie R. .

BREAST CANCER RESEARCH, 2012, 14 (01)

[3]

Angst BD, 2001, J CELL SCI, V114, P629

[4]

[Anonymous], 2007, BREAST CANC RES, DOI DOI 10.1186/BCR1771

[5]

[Anonymous], 2018, ONCOIMMUNOLOGY, DOI DOI 10.1080/2162402X.2018.1509820

[6] Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer [J].

Ao, Zheng ;

Shah, Sanket H. ;

Machlin, Leah M. ;

Parajuli, Ritesh ;

Miller, Philip C. ;

Rawal, Siddarth ;

Williams, Anthony J. ;

Cote, Richard J. ;

Lippman, Marc E. ;

Datar, Ram H. ;

El-Ashry, Dorraya .

CANCER RESEARCH, 2015, 75 (22) :4681-4687

[7] Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series [J].

Azevedo Koike Folgueira, Maria Aparecida ;

Maistro, Simone ;

Hirata Katayama, Maria Lucia ;

Roela, Rosimeire Aparecida ;

Lopes Mundim, Fiorita Gonzales ;

Nanogaki, Suely ;

de Bock, Geertruida H. ;

Brentani, M. Mitzi .

BIOSCIENCE REPORTS, 2013, 33 :921-929

[8] Constitutive activation of STAT3 in breast cancer cells: A review [J].

Banerjee, Kasturi ;

Resat, Haluk .

INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (11) :2570-2578

[9] Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs) [J].

Bartosh, Thomas J. ;

Ullah, Mujib ;

Zeitouni, Suzanne ;

Beaver, Joshua ;

Prockop, Darwin J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (42) :E6447-E6456

[10] TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells [J].

Bartucci, M. ;

Dattilo, R. ;

Moriconi, C. ;

Pagliuca, A. ;

Mottolese, M. ;

Federici, G. ;

Di Benedetto, A. ;

Todaro, M. ;

Stassi, G. ;

Sperati, F. ;

Amabile, M. I. ;

Pilozzi, E. ;

Patrizii, M. ;

Biffoni, M. ;

Maugeri-Sacca, M. ;

Piccolo, S. ;

De Maria, R. .

ONCOGENE, 2015, 34 (06) :681-690

← 1 2 3 4 5 6 7 8 9 10 →