Synthesis and Antiviral Activity of Amino-Acid Conjugates of Glycyrrhetic Acid

被引：10

作者：

Baltina, L. A., Jr. ^{[1
]}

Khudobko, M. V. ^{[1
]}

Mikhailova, L. R. ^{[1
]}

Baltina, L. A. ^{[1
]}

Fedorova, V. A. ^{[2
]}

Orshanskaya, Ya. A. ^{[2
]}

Zarubaev, V. V. ^{[2
]}

Kiselev, O. I. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Russia

[2] Minist Healthcare Russian Federat, Res Inst Influenza, St Petersburg 197376, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 03期

关键词：

triterpenoids; licorice; glycyrrhetic acid; acid chloride; amino acids; influenza A/H1N1 virus; antiviral activity;

D O I：

10.1007/s10600-014-0990-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conjugates of glycyrrhetic acid (GLA) with amino acids (L-isoleucine, -leucine, -valine, and -phenylalanine) were synthesized by the acid-chloride method using methyl or tert-butyl esters of the acids. Tests in MDCK cell culture showed that the GLA conjugate with phenylalanine exhibited high antiviral activity against influenza A/H1N1/pdm09 virus (ED50 = 4.4 mu g/mL, SI = 161).

引用

页码：473 / 477

页数：5

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