The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups

被引：408

作者：

Trost, Barry M. ^{[1
]}

Weiss, Andrew H. ^{[2
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 7-8期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

alkynylation; catalytic asymmetric synthesis; propargylic alcohols; propargylic amines; CATALYTIC ASYMMETRIC ADDITION; IN-SITU GENERATION; PONNDORF-VERLEY ALKYNYLATION; CONJUGATE ADDITION; TERMINAL ALKYNES; PROPARGYLIC ALCOHOLS; AROMATIC-ALDEHYDES; GAMMA-HYDROXY-ALPHA; BETA-ACETYLENIC ESTERS; ALKYNYLZINC REAGENTS; PHENYLACETYLENE ADDITIONS;

D O I：

10.1002/adsc.200800776

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights and compares the available methods for these transformations.

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页码：963 / 983

页数：21

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