NIR-Laser-Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors

被引：252
作者：
Meng, Zhouqi [1 ]
Wei, Fang [2 ]
Wang, Ronghua [2 ]
Xia, Mengge [1 ]
Chen, Zhigang [1 ]
Wang, Huiping [2 ]
Zhu, Meifang [1 ]
机构：
[1] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Coll Mat Sci & Engn, Shanghai 201620, Peoples R China
[2] Shanghai Jiao Tong Univ, Peoples Hosp 1, Expt Res Ctr, Shanghai 201620, Peoples R China
来源：
ADVANCED MATERIALS | 2016年 / 28卷 / 02期
基金：
中国国家自然科学基金;
关键词：
GOLD NANOCAGES; GRAPHENE OXIDE; DRUG; CANCER; NANOPARTICLES; RELEASE; POLYMERS; ABLATION; AGENT; LIPOSOMES;
D O I：
10.1002/adma.201502669
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In vivo MEO2MA@MEO2MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：245 / 253
页数：9
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