SINEs of cancer therapy success without ADAR1

被引：2

作者：

Zlotorynski, Eytan

机构：

[1] Nature Reviews Molecular Cell Biology,

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2020年 / 21卷 / 12期

关键词：

D O I：

10.1038/s41580-020-00310-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem-loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.

引用

页码：713 / 713

页数：1

共 2 条

[1] Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
Mehdipour, Parinaz
Marhon, Sajid A.
Ettayebi, Ilias
Chakravarthy, Ankur
Hosseini, Amir
Wang, Yadong
de Castro, Fabiola Attie
Loo Yau, Helen
Ishak, Charles
Abelson, Sagi
O'Brien, Catherine A.
De Carvalho, Daniel D.
[J]. NATURE, 2020, 588 (7836) : 169 - +
[2] Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery
Nair, Lekha
Chung, Hachung
Basu, Uttiya
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020, 21 (03) : 123 - 136

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