Lung Cancer in Combined Pulmonary Fibrosis and Emphysema A Series of 47 Western Patients

被引:57
作者
Girard, Nicolas [1 ,2 ]
Marchand-Adam, Sylvain [3 ]
Naccache, Jean-Marc [4 ,5 ]
Borie, Raphael [6 ]
Urban, Thierry [7 ]
Jouneau, Stephane [8 ]
Marchand, Eric [9 ]
Ravel, Anne-Claire [10 ]
Kiakouama, Lize [1 ,2 ]
Etienne-Mastroianni, BeneDicte [1 ,2 ]
Cadranel, Jacques [4 ,5 ]
Cottin, Vincent [1 ,2 ]
Cordier, Jean-Francois [1 ,2 ]
机构
[1] Hosp Civils Lyon, Hop Louis Pradel, Natl Reference Ctr Rare Pulm Dis, Dept Resp Med, Lyon, France
[2] Univ Lyon 1, F-69365 Lyon, France
[3] Univ Tours, CHRU Tours, Dept Resp Med, INSERM UMR 1100, Tours, France
[4] Hop Tenon, AP HP, Reg Reference Ctr Rare Pulm Dis, Chest Dept,Expert Ctr Thorac Oncol, F-75970 Paris, France
[5] Univ Paris 06, Paris, France
[6] Hop Bichat Claude Bernard, AP HP, Competence Ctr Rare Pulm Dis, Dept Resp Med, F-75877 Paris, France
[7] CHU Angers, Dept Resp Med, Angers, France
[8] Univ Rennes 1, IRSET UMR 1085, Hop Pontchaillou, Dept Resp Med,Competence Ctr Rare Pulm Dis, Rennes, France
[9] Catholic Univ Louvain, CHU Mt Godine, Dept Resp Med, Yvoir, Belgium
[10] Hop Bourgoin Jallieu, Pulmonol Serv, Bourgoin Jallieu, France
关键词
Combined pulmonary fibrosis and emphysema syndrome; Lung cancer; Orphan disease; Tobacco smoking; RESOLUTION COMPUTED-TOMOGRAPHY; ACUTE EXACERBATION; RISK; RADIOTHERAPY; CT; RECOMMENDATIONS; STATEMENT; SMOKING;
D O I
10.1097/JTO.0000000000000209
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterized by imaging features consisting of the association of centrilobular and/or paraseptal emphysema and pulmonary fibrosis. Virtually all patients are smokers and thus at high risk of developing lung cancer. Methods: This retrospective multicentre study was conducted by the Groupe d'Etudes et de Recherche sur les Maladies " Orphelines" Pulmonaires (GERM" O" P). Results: A total of 47 patients presenting with lung cancer and CPFE syndrome were identified. All patients were smokers, with a mean of 47 pack-years. A pathological diagnosis of lung cancer was obtained for 38 (81%) patients. Histological type was squamous cell carcinoma in 17 (36%) patients, adenocarcinoma in 14 (30%), nonsmall- cell lung cancer not otherwise specified in three (6%), smallcell lung cancer in three (6%), and sarcomatoid carcinoma in one (2%). Overall, 20 of the 47 patients could not receive standard-ofcare treatment for lung cancer, as per international recommendations or guidelines; this limitation was considered to be directly related to the CPFE syndrome in eight (40%) cases. Conclusion: Lung cancer in patients with CPFE syndrome represents a specific entity with a poor prognosis, that further represents the most characteristic and severe model of tobacco-related disease.
引用
收藏
页码:1162 / 1170
页数:9
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