Cu(OTf)2/Et3N-promoted cyclocondensation of activated α-methylene alkenes and nitroolefins: a novel one-pot synthesis of polysubstituted benzenes

被引：28

作者：

Su, Weike ^{[1
]}

Ding, Kai ^{[1
]}

Chen, Zhiwei ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Minist Educ, Key Lab Pharmaceut Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Copper triflate; Activated alkenes; Nitroolefins; One-pot; Polysubstituted benzenes; SOLVENT-FREE CONDITIONS; BIOLOGICAL EVALUATION; TYROSINE KINASES; EFFICIENT METHOD; ATOM ECONOMY; BENZANNULATION; DERIVATIVES; INHIBITORS; TRIFLATE; ALKYNES;

D O I：

10.1016/j.tetlet.2008.11.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient one-pot synthesis of polyfunctionalized benzenes has been developed via cyclocondensation of activated alpha-methylene alkenes such as vinyl malononitriles and ethyl vinyl cyanoacetates with nitroolefins using Cu(OTf)(2)/Et3N as a novel catalytic system. (C) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：636 / 639

页数：4

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