Nano-loaded natural killer cells as carriers of indocyanine green for synergetic cancer immunotherapy and phototherapy

被引：22
作者：
Huang, Shigao [1 ,2 ]
Fong, Chi Ian [1 ,2 ]
Xu, Mengze [1 ,2 ]
Han, Bing-nan [3 ]
Yuan, Zhen [1 ,2 ]
Zhao, Qi [1 ,2 ]
机构：
[1] Univ Macau, Ctr Canc, Fac Hlth Sci, Taipa, Macao, Peoples R China
[2] Univ Macau, Inst Translat Med, Fac Hlth Sci, Taipa, Macao, Peoples R China
[3] Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China
来源：
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES | 2019年 / 12卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Nanoparticle; NK cell; photothermal therapy; cancer theranostics; ANTIBODY FRAGMENTS; AFFINITY; BINDING;
D O I：
10.1142/S1793545819410025
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
To improve the efficacy of traditional chemotherapy and radiotherapy and reduce their serious side effects, further efforts need to be exerted to identify better cancer therapeutic options that are effective, affordable, and acceptable to patients. In this study, a novel theranostic agent was produced to perform synergetic cancer immunotherapy and phototherapy. The theranostic agent, named natural killer ( NK) cells carrying indocyanine green loaded liposomes was synthesized NK cells with ICG nanoparticles to serve as the agent for a newly-established cancer treatment. It is expected that the developed synergistic therapy can pave a new avenue for improved efficacy of cancer theranostics.
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页数：8
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