Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication

被引：27

作者：

Gardner, Andrew W. ^{[1
,2
]}

Parker, Donald E. ^{[3
]}

Montgomery, Polly S. ^{[1
]}

Blevins, Steve M. ^{[4
]}

Teague, April M. ^{[5
]}

Casanegra, Ana I. ^{[6
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Donald W Reynolds Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK 73117 USA

[2] Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK 73117 USA

[4] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Gen Internal Med Sect, Oklahoma City, OK USA

[5] Univ Oklahoma, Hlth Sci Ctr, CMRI Diabet & Metab Res Program, Oklahoma City, OK 73117 USA

[6] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Cardiovasc Sect, Oklahoma City, OK 73117 USA

来源：

ANGIOLOGY | 2014年 / 65卷 / 06期

关键词：

claudication; C-reactive protein; oxidized low-density lipoprotein; peripheral artery disease; PERIPHERAL ARTERIAL-DISEASE; C-REACTIVE PROTEIN; PHYSICAL-ACTIVITY; LOWER-EXTREMITY; EXERCISE; MORTALITY;

D O I：

10.1177/0003319713489769

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n = 134) limited by claudication were studied. Patients took 3275 +/- 1743 daily strides for 273 +/- 112 minutes each day, and their average daily cadence was 11.7 +/- 2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides (P<.001), total daily ambulatory time (P<.01), peak activity index (P<.01), daily average cadence (P <.05), and the maximum cadences for 60 minutes (P<.05), 30 minutes (P <.05), 20 minutes (P <.05), and 5 minutes (P<.01). Oxidized low-density lipoprotein and soluble vascular cell adhesion molecule 1 were not significantly associated with any of the ambulatory measures (P>05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation but are not associated with markers of oxidative stress.

引用

页码：491 / 496

页数：6

共 29 条

[1] Review of mortality and cardiovascular event rates in patients enrolled in clinical trials for claudication therapies [J].