Total Synthesis of (-)-Crinipellin A

被引:63
作者
Kang, Taek [1 ]
Song, Seog Boem [1 ]
Kim, Won-Yeob [1 ]
Kim, Byung Gyu [1 ]
Lee, Hee-Yoon [1 ]
机构
[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea
基金
新加坡国家研究基金会;
关键词
1,3-DIYL TRAPPING REACTION; TRIMETHYLENEMETHANE DIYLS; CYCLOADDITION REACTIONS; ASYMMETRIC INDUCTION; CARBONYL-COMPOUNDS; DIAZO-COMPOUNDS; IDEAL SYNTHESIS; CRINIPELLIN B; TRIQUINANES; OXIDATION;
D O I
10.1021/ja5054412
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The first total synthesis of (-)-crinipellin A is described. The tetraquinane core skeleton of crinipellin A was assembled through the tandem [2 + 3] cycloaddition reaction of an allenyl diazo substrate containing a cyclopentane ring in a single operation. The absolute stereochemistry was confirmed through the total synthesis.
引用
收藏
页码:10274 / 10276
页数:3
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