Total Synthesis of (-)-Crinipellin A

被引：63

作者：

Kang, Taek ^{[1
]}

Song, Seog Boem ^{[1
]}

Kim, Won-Yeob ^{[1
]}

Kim, Byung Gyu ^{[1
]}

Lee, Hee-Yoon ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 29期

基金：

新加坡国家研究基金会;

关键词：

1,3-DIYL TRAPPING REACTION; TRIMETHYLENEMETHANE DIYLS; CYCLOADDITION REACTIONS; ASYMMETRIC INDUCTION; CARBONYL-COMPOUNDS; DIAZO-COMPOUNDS; IDEAL SYNTHESIS; CRINIPELLIN B; TRIQUINANES; OXIDATION;

D O I：

10.1021/ja5054412

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of (-)-crinipellin A is described. The tetraquinane core skeleton of crinipellin A was assembled through the tandem [2 + 3] cycloaddition reaction of an allenyl diazo substrate containing a cyclopentane ring in a single operation. The absolute stereochemistry was confirmed through the total synthesis.

引用

页码：10274 / 10276

页数：3

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