Predictors of Poor Outcome in ANCA-Associated Vasculitis (AAV)

被引：17

作者：

Vega, Luis E. ^{[1
]}

Espinoza, Luis R. ^{[2
]}

机构：

[1] Hosp Cent Fuerza Aerea, Serv Reumatol, Lima, Peru

[2] Louisiana State Univ, Hlth Sci Ctr, 433 Bolivar St, New Orleans, LA 70112 USA

来源：

CURRENT RHEUMATOLOGY REPORTS | 2016年 / 18卷 / 12期

关键词：

ANCA-associated vasculitis; Granulomatosis with polyangiitis; Eosinophilic granulomatosis with polyangiitis; Microscopic polyangiitis; Poor outcome; Biomarkers; ANTIBODY-ASSOCIATED GLOMERULONEPHRITIS; DISEASE-ACTIVITY; HISTOPATHOLOGIC CLASSIFICATION; HISTOLOGICAL CLASSIFICATION; CLINICAL-OUTCOMES; RENAL SURVIVAL; RELAPSE; EXPRESSION; BIOMARKERS; GENES;

D O I：

10.1007/s11926-016-0619-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is important to recognize factors that might predict poor outcome and prognosis in patients with AAV. The predictors reported in the literature encompass genetic, histopathological, and clinical ones. Genetic studies (genetic predictors) have found genes that are associated with prediction of poor response to treatment, deterioration of renal function, and risk of mortality. Histopathological studies (histopathological predictors) have shown that sclerotic renal lesions are associated with increased risk of progression to end-stage renal disease and death. Lastly, scores (clinical predictors) obtained with tool as FFS, Maldini risk score, VDI, and emerging new biomarkers could potentially be helpful in assessment of prognosis in the future.

引用

页数：7

共 41 条

[1] Histopathologic Classification of ANCA-Associated Glomerulonephritis [J].

Berden, Annelies E. ;

Ferrario, Franco ;

Hagen, E. Christiaan ;

Jayne, David R. ;

Jennette, J. Charles ;

Joh, Kensuke ;

Neumann, Irmgard ;

Noel, Laure-Helene ;

Pusey, Charles D. ;

Waldherr, Ruediger ;

Bruijn, Jan A. ;

Bajema, Ingeborg M. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (10) :1628-1636

[2] Damage Assessment in ANCA-Associated Vasculitis [J].

Bhamra, Kuljeet ;

Luqmani, Raashid .

CURRENT RHEUMATOLOGY REPORTS, 2012, 14 (06) :494-500

[3] CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN [J].

Brix, Silke R. ;

Stege, Gesa ;

Disteldorf, Erik ;

Hoxha, Elion ;

Krebs, Christian ;

Krohn, Sonja ;

Otto, Benjamin ;

Klaetschke, Kristin ;

Herden, Elisabeth ;

Heymann, Felix ;

Lira, Sergio A. ;

Tacke, Frank ;

Wolf, Gunter ;

Busch, Martin ;

Jabs, Wolfram J. ;

Oezcan, Fedai ;

Keller, Frieder ;

Beige, Joachim ;

Wagner, Karl ;

Helmchen, Udo ;

Noriega, Mercedes ;

Wiech, Thorsten ;

Panzer, Ulf ;

Stahl, Rolf A. K. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (09) :2105-2117

[4] PTPN22 R620W Polymorphism and ANCA Disease Risk in White Populations: A Metaanalysis [J].

Cao, Yali ;

Liu, Kuo ;

Tian, Zhigang ;

Hogan, Susan L. ;

Yang, Jiajin ;

Poulton, Caroline J. ;

Falk, Ronald J. ;

Li, Wenge .

JOURNAL OF RHEUMATOLOGY, 2015, 42 (02) :292-299

[5] Predictors of Treatment Resistance and Relapse in Chinese Patients with Antineutrophil Cytoplasmic Antibody-associated Disease [J].

Cao, Yali ;

Tian, Zhigang ;

Li, Wenge ;

Ma, Li ;

Yu, Yongchao ;

Ren, Wenwen .

JOURNAL OF RHEUMATOLOGY, 2014, 41 (05) :916-922

[6] Association of HLA Genes with Clinical Outcomes of ANCA-Associated Vasculitis [J].

Chang, Dong-yuan ;

Luo, Huan ;

Zhou, Xu-jie ;

Chen, Min ;

Zhao, Ming-Hui .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 7 (08) :1293-1299

[7] Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center [J].

Chang, Dong-yuan ;

Wu, Li-hua ;

Liu, Gang ;

Chen, Min ;

Kallenberg, Cees G. M. ;

Zhao, Ming-Hui .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 (06) :2343-2349

[8] Are urinary levels of high mobility group box 1 markers of active nephritis in anti-neutrophil cytoplasmic antibody-associated vasculitis? [J].

de Souza, A. W. S. ;

Abdulahad, W. H. ;

Sosicka, P. ;

Bijzet, J. ;

Limburg, P. C. ;

Stegeman, C. A. ;

Bijl, M. ;

Westra, J. ;

Kallenberg, C. G. M. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 178 (02) :270-278

[9] Serum Biomarkers in Patients with Relapsing Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss) [J].

Dejaco, Christian ;

Oppl, Bastian ;

Monach, Paul ;

Cuthbertson, David ;

Carette, Simon ;

Hoffman, Gary ;

Khalidi, Nader ;

Koening, Curry ;

Langford, Carol ;

McKinnon-Maksimowicz, Kathleen ;

Seo, Philip ;

Specks, Ulrich ;

Ytterberg, Steven ;

Merkel, Peter A. ;

Zwerina, Jochen .

PLOS ONE, 2015, 10 (03)

[10]

Ellis CL, 2012, J AM SOC NEPHROL, V23, p711A

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