Patent foramen ovale and cerebrovascular diseases

被引：33

作者：

Desai, Amish J. ^{[1
]}

Fuller, Cindy J. ^{[1
]}

T Jesurum, Jill ^{[1
]}

Reisman, Mark ^{[1
]}

机构：

[1] Swedish Med Ctr, Dept Cardiovasc Res & Sci Dev, Seattle, WA 98104 USA

来源：

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE | 2006年 / 3卷 / 08期

关键词：

cryptogenic stroke; migraine headache; paradoxical embolism; patent foramen ovale; transcatheter closure;

D O I：

10.1038/ncpcardio0597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patent foramen ovale (PFO) has been linked to ischemic strokes of undetermined cause (cryptogenic strokes). PFO-a remnant of fetal circulation when the foramen ovale does not seal after birth-can permit microemboli to escape the pulmonary filter into the intracranial circulation, causing stroke. Coexistent atrial septal aneurysm, pelvic deep vein thrombosis and inherited clotting factor deficiencies could potentiate stroke risk in patients with PFO. Transcatheter PFO closure, a minimally invasive procedure, is one technique used to prevent recurrent cerebrovascular events. A connection between PFO and migraine headache has been conceptualized from retrospective evidence of reduced migraine frequency and severity after PFO closure; however, prospective randomized trials are needed to verify the efficacy of PFO closure on migraine prevention. In this review we discuss embryologic origins, diagnostic techniques and treatment options for prevention of paradoxical embolism thought to be related to PFO, and the relation of PTO to cryptogenic stroke and migraine.

引用

页码：446 / 455

页数：10

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