Drug repurposing approaches to fight Dengue virus infection and related diseases

被引：44
|
作者：
Botta, Lorenzo [1 ]
Rivara, Mirko [2 ]
Zuliani, Valentina [2 ]
Radi, Marco [2 ]
机构：
[1] Univ Tuscia, Biol & Ecol Dept DEB, I-01100 Viterbo, Italy
[2] Univ Parma, Dept Food & Drug, Viale Sci 27-A, I-43124 Parma, Italy
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷
关键词：
Dengue virus; Neglected Diseases; Drug repurposing; Review; POTENT INHIBITOR; MYCOPHENOLIC-ACID; HELICASE ACTIVITY; REPLICATION; PROTEIN; CELGOSIVIR; IVERMECTIN; NELFINAVIR; DISCOVERY; FEVER;
D O I：
10.2741/4630
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropod-born viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention. Herein, we will describe the most recent drug repurposing approaches to fight DENV infection and their implications in antiviral drug-discovery.
引用
收藏
页码：997 / 1019
页数：23
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