Alkylated sugar amino acids:: A new entry toward highly functionalized dipeptide isosters

被引：38
作者：
Raunkjær, M [1 ]
El Oualid, F [1 ]
van der Marel, GA [1 ]
Overkleeft, HS [1 ]
Overhand, M [1 ]
机构：
[1] Leiden Univ, Gorlaeus Labs, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 18期
关键词：
D O I：
10.1021/ol048750r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel highly functionalized dipeptide isosters are synthesized via a diastereoselective alkyl/arylation protocol of a glucose-derived (R)-tert-butanesulfinylimine. One of these novel sugar amino acid derivatives, a D-Ala-Ser/Thr isostere, was applied in a peptide synthesis protocol to afford a cyclic tetramer.
引用
收藏
页码：3167 / 3170
页数：4
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