IL-33 in Chronic Respiratory Disease: From Preclinical to Clinical Studies

被引：35

作者：

Donovan, Chantal ^{[1
,2
,3
,4
]}

Hansbro, Philip M. ^{[1
,2
,3
]}

机构：

[1] Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia

[2] Univ Technol Sydney, Fac Sci, Sydney, NSW 2050, Australia

[3] Univ Newcastle, Prior Res Ctr Hlth Lungs, Hunter Med Res Inst, Newcastle, NSW 2308, Australia

[4] Royal Prince Alfred Hosp Grounds, Centenary Inst, Ctr Inflammat, Bldg 93,John Hopkins Dr, Camperdown, NSW 2050, Australia

来源：

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | 2020年 / 3卷 / 01期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

IL-33; anti-IL-33; ST2; eosinophils; asthma; COPD; THYMIC STROMAL LYMPHOPOIETIN; VIRUS-INDUCED ASTHMA; TYPE-2; INFLAMMATION; AIRWAY INFLAMMATION; PROGENITOR CELLS; CYTOKINE; LUNG; INTERLEUKIN-33; EXACERBATIONS; PREDISPOSES;

D O I：

10.1021/acsptsci.9b00099

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

IL-33 has been deorphanized as a member of the IL-1 family and has key roles as an alarmin and cytokine with potent capacity to drive type 2 inflammation. This has led to a plethora of studies surrounding its role in chronic diseases with a type 2 inflammatory component. Here, we review the roles of IL-33 in two chronic respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD). We discuss the hallmark and paradigm-shifting studies that have contributed to our understanding of IL-33 biology. We cover animal studies that have elucidated the mechanisms of IL-33 and assessed the role of anti-IL-33 treatment and immunization against IL-33. We highlight key clinical evidence for the potential of targeting increased IL-33 in respiratory diseases including exacerbations, and we outline current clinical trials using an anti-IL-33 monoclonal antibody in asthma patients. Finally, we discuss some of the challenges that have arisen in IL-33 biology and highlight potential future directions in targeting this cytokine in chronic respiratory diseases.

引用

页码：56 / 62

页数：7

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