Arg-Ile-Tyr (RIY) derived from rapeseed protein decreases food intake and gastric emptying after oral administration in mice

被引：31

作者：

Marczak, Ewa D.

Ohinata, Kousaku

Lipkowski, Andrzej W.

Yoshikawa, Masaaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Kyoto 6110011, Japan

[2] NIEHS, Lab Pharmacol & Chem, Med Chem Grp, Res Triangle Pk, NC 27709 USA

[3] Polish Acad Sci, Med Res Ctr, PL-02106 Warsaw, Poland

来源：

PEPTIDES | 2006年 / 27卷 / 09期

关键词：

rapeseed; food intake; gastric emptying; CCK1; receptor;

D O I：

10.1016/j.peptides.2006.03.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously reported that a bioactive tripeptide Arg-Ile-Tyr,(RIY), which has been isolated as an inhibitor for angiotensin I-converting enzyme from the subtilisin digest of rapeseed protein, decreased blood pressure. In this study, we also found that RIY dose-dependently decreased food intake at a dose of 150 mg/kg after oral administration in fasted ddY male mice. The anorexigenic action of RIY was blocked by a cholecystokinin-1 CCK1 receptor antagonist, lorglumide. RIY also decreased the gastric emptying rate at a dose of 150 mg/kg and the RIY-induced delay of gastric emptying was blocked by lorglumide. However, RIY had no affinity for CCK1 receptor. Taken together, RIY decreased food intake and gastric emptying by stimulating CCK release. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：2065 / 2068

页数：4

共 15 条

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