Hepatitis D Viremia Among Injection Drug Users in San Francisco

被引：25

作者：

Mahale, Parag ^{[1
]}

Aka, Peter, V ^{[1
,2
]}

Chen, Xiaohua ^{[3
,4
]}

Liu, Ping ^{[3
]}

Fram, Benjamin J. ^{[5
]}

Wang, Alan S. ^{[1
]}

Simenel, Scott ^{[5
]}

Tseng, Fan-Chen ^{[1
]}

Chen, Sabrina ^{[6
]}

Edlin, Brian R. ^{[7
,8
]}

Glenn, Jeffrey S. ^{[3
,5
]}

O'Brien, Thomas R. ^{[1
]}

机构：

[1] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA

[2] ICF Int, Demog & Hlth Surveys, Rockville, MD USA

[3] Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

[4] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Infect Dis, Shanghai, Peoples R China

[5] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Palo Alto, CA 94304 USA

[6] Informat Management Serv Inc, Calverton, MD USA

[7] Univ Calif San Francisco, Urban Hlth Study, San Francisco, CA 94143 USA

[8] Weill Cornell Med Coll, Dept Med, New York, NY USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 217卷 / 12期

基金：

美国国家卫生研究院;

关键词：

epidemiology; hepatitis B virus; hepatitis C virus; hepatitis D virus; HDV RNA; people who injected drugs; treatment; viremia; B-VIRUS; C VIRUS; DELTA-HEPATITIS; LOS-ANGELES; PREVALENCE; EPIDEMIOLOGY; COINFECTION; INFECTION; ANTIBODY;

D O I：

10.1093/infdis/jiy157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

People who inject drugs (PWID) are commonly exposed to hepatitis B virus (HBV) and hepatitis D virus (HDV). We evaluated the prevalence of HDV viremia among hepatitis B surface antigen (HBsAg)-positive PWID (n = 73) using a new quantitative microarray antibody capture (Q-MAC) assay, HDV western blot, and HDV RNA. HDV Q-MAC performed well in this cohort: anti-HDV, 100% sensitivity and specificity; HDV viremia, 61.5% sensitivity and 100% specificity. Hepatitis D viremia was present in 35.6% of HBsAg-positive participants and was more common in those with resolved compared to chronic hepatitis C (5.1% vs 0.6%; adjusted odds ratio, 9.80; P<.0001).

引用

页码：1902 / 1906

页数：5

共 15 条

[1] Epidemiology of viral hepatitis and HIV co-infection [J].

Alter, MJ .

JOURNAL OF HEPATOLOGY, 2006, 44 :S6-S9

[2] Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus: A Review of Cases Reported to the US Food and Drug Administration Adverse Event Reporting System [J].

Bersoff-Matcha, Susan J. ;

Cao, Kelly ;

Jason, Mihaela ;

Ajao, Adebola ;

Jones, S. Christopher ;

Meyer, Tamra ;

Brinker, Allen .

ANNALS OF INTERNAL MEDICINE, 2017, 166 (11) :792-798

[3] Hepatitis B, C, and D virus infection showing distinct patterns between injection drug users and the general population [J].

Chen, Fei ;

Zhang, Jian ;

Guo, Fengfan ;

Wen, Bo ;

Luo, Shan ;

Yuan, Dongping ;

Lin, Yingbiao ;

Ou, Wensheng ;

Tang, Ping ;

Dai, Guozhi ;

Li, Fangfang ;

Liu, Wenpei ;

Qu, Xiaowang .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2017, 32 (02) :515-520

[4] A Novel Quantitative Microarray Antibody Capture Assay Identifies an Extremely High Hepatitis Delta Virus Prevalence Among Hepatitis B Virus-Infected Mongolians [J].

Chen, Xiaohua ;

Oidovsambuu, Odgerel ;

Liu, Ping ;

Grosely, Rosslyn ;

Elazar, Menashe ;

Winn, Virginia D. ;

Fram, Benjamin ;

Boa, Zhang ;

Dai, Hongjie ;

Dashtseren, Bekhbold ;

Yagaanbuyant, Dahgwahdorj ;

Genden, Zulkhuu ;

Dashdorj, Naranbaatar ;

Bungert, Andreas ;

Dashdorj, Naranjargal ;

Glenn, Jeffrey S. .

HEPATOLOGY, 2017, 66 (06) :1739-1749

[5] EXPERIENCE WITH HUMAN IMMUNODEFICIENCY VIRUS-INFECTION IN PATIENTS WITH HEPATITIS-B VIRUS AND HEPATITIS DELTA VIRUS-INFECTIONS IN LOS-ANGELES, 1977-1985 [J].

DECOCK, KM ;

NILAND, JC ;

LU, HP ;

RAHIMIAN, A ;

EDWARDS, V ;

SHRIVER, K ;

GOVINDARAJAN, S ;

REDEKER, AG .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 127 (06) :1250-1260

[6] INFLUENCE OF HEPATITIS-DELTA-VIRUS INFECTION ON PROGRESSION TO CIRRHOSIS IN CHRONIC HEPATITIS TYPE-B [J].

FATTOVICH, G ;

BOSCARO, S ;

NOVENTA, F ;

PORNARO, E ;

STENICO, D ;

ALBERTI, A ;

RUOL, A ;

REALDI, G .

JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (05) :931-935

[7]

GOVINDARAJAN S, 1983, GASTROENTEROLOGY, V85, P160

[8] Hepatitis Delta: Seek and Ye Shall Find [J].

Holmberg, Scott D. ;

Ward, John W. .

JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (06) :822-824

[9] A Population-Based Study of Hepatitis D Virus as Potential Risk Factor for Hepatocellular Carcinoma [J].

Ji, Jianguang ;

Sundquist, Kristina ;

Sundquist, Jan .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (10) :790-792

[10] Delta Hepatitis: Toward Improved Diagnostics [J].

Kamili, Saleem ;

Drobeniuc, Jan ;

Mixson-Hayden, Tonya ;

Kodani, Maja .

HEPATOLOGY, 2017, 66 (06) :1716-1718

← 1 2 →