Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides

被引：68
|
作者：
Prunier, AL
Malbruny, B
Tandé, D
Picard, B
Leclercq, R
机构：
[1] CHU Morvan, Microbiol Serv, Brest, France
[2] CHU Cote Nacre, Microbiol Serv, Caen, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 09期
关键词：
D O I：
10.1128/AAC.46.9.3054-3056.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.
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收藏
页码：3054 / 3056
页数：3
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