A Different Approach to Enantioselective Organic Synthesis: Absolute Asymmetric Synthesis of Organometallic Reagents

被引：46

作者：

Lennartson, Anders ^{[1
]}

Olsson, Susanne ^{[1
]}

Sundberg, Jonas ^{[1
]}

Hakansson, Mikael ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem, S-41296 Gothenburg, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 17期

基金：

瑞典研究理事会;

关键词：

asymmetric synthesis; crystal growth; zinc; spontaneous resolution; synthetic methods; SOLID-STATE; GRIGNARD-REAGENTS; CHIRAL CRYSTALS; CONFIGURATION; CHLORINATION; RESOLUTION; COMPLEXES;

D O I：

10.1002/anie.200806222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Voilà, optical activity: Both enantiomers of 1-chloroindene have been synthesized in high selectivity from solely achiral starting materials, and without using optically active catalysts (see scheme). These symmetry-breaking syntheses provide a proof-of-concept for a new approach to asymmetric synthesis. NCS=N-chlorosuccinimide. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3137 / 3140

页数：4

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