Advances in understanding the regulatory mechanism of cholesterol 7α-hydroxylase

被引：25
作者：
Ge, Mao-xu [1 ,2 ]
Shao, Rong-guang [1 ,2 ]
He, Hong-wei [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Biotechnol, NHFPC, Key Lab Biotechnol Antibiot, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2019年 / 164卷
基金：
中国国家自然科学基金;
关键词：
CYP7A1; Bile acid; microRNAs; Gut microbiome; Hypercholesterolemia; FARNESOID-X-RECEPTOR; FIBROBLAST-GROWTH-FACTOR; BILE-ACID METABOLISM; NUCLEAR FACTOR 4-ALPHA; DIFFERENTIAL REGULATION; INTRAHEPATIC CHOLESTASIS; SIGNALING PATHWAY; MESSENGER-RNA; UP-REGULATION; HUMAN CYP7A1;
D O I：
10.1016/j.bcp.2019.04.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The conversion of cholesterol to bile acids (BAs) contributes to the elimination of total cholesterol from the body. In addition, manipulating BA homeostasis by modulating cholesterol 7 alpha-hydroxylase (CYP7A1) may affect the metabolic processing of cholesterol, exerting therapeutic effects on hypercholesterolemia and cardiovascular diseases. Multiple mechanisms (such as various nuclear receptors and regulatory factors) are involved in CYP7A1 modulation. Recently, microRNAs, protein degradation pathways, and the gut microbiota have been identified to participate in these sophisticated networks. In this review, research progress on the regulatory mechanism of CYP7A1 is summarized.
引用
收藏
页码：152 / 164
页数：13
相关论文
共 161 条
[21]  
Claudel T, 2002, J CLIN INVEST, V109, P961
[22]   CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR (COUP-TF) DIMERS BIND TO DIFFERENT GGTCA RESPONSE ELEMENTS, ALLOWING COUP-TF TO REPRESS HORMONAL INDUCTION OF THE VITAMIN-D(3), THYROID-HORMONE, AND RETINOIC ACID RECEPTORS [J].
COONEY, AJ ;
TSAI, SY ;
OMALLEY, BW ;
TSAI, MJ .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (09) :4153-4163
[23]   MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth [J].
Corney, David C. ;
Flesken-Nikitin, Andrea ;
Godwin, Andrew K. ;
Wang, Wei ;
Nikitin, Alexander Yu. .
CANCER RESEARCH, 2007, 67 (18) :8433-8438
[24]  
Crestani M, 1998, J LIPID RES, V39, P2192
[25]   miR-497 accelerates oxidized low-density lipoprotein-induced lipid accumulation in macrophages by repressing the expression of apelin [J].
Cui, Junfeng ;
Ren, Zhong ;
Zou, Wenshuang ;
Jiang, Yanling .
CELL BIOLOGY INTERNATIONAL, 2017, 41 (09) :1012-1019
[26]   Induction of hepatic miR-34a by perfluorooctanoic acid regulates metabolism-related genes in mice [J].
Cui, Ruina ;
Li, Chenyang ;
Wang, Jianshe ;
Dai, Jiayin .
ENVIRONMENTAL POLLUTION, 2019, 244 :270-278
[27]   Cholesterol Transport Revisited: A New Turbo Mechanism to Drive Cholesterol Excretion [J].
de Boer, Jan Freark ;
Kuipers, Folkert ;
Groen, Albert K. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2018, 29 (02) :123-133
[28]   Agaricus brasiliensis (sun mushroom) affects the expression of genes related to cholesterol homeostasis [J].
de Miranda, Aline Mayrink ;
Rossoni Junior, Joamyr Victor ;
Souza e Silva, Lorena ;
dos Santos, Rinaldo Cardoso ;
Silva, Marcelo Eustaquio ;
Pedrosa, Maria Lucia .
EUROPEAN JOURNAL OF NUTRITION, 2017, 56 (04) :1707-1717
[29]   The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism [J].
Demetz, Egon ;
Schroll, Andrea ;
Auer, Kristina ;
Heim, Christiane ;
Patsch, Josef R. ;
Eller, Philipp ;
Theurl, Markus ;
Theurl, Igor ;
Theurl, Milan ;
Seifert, Markus ;
Lener, Daniela ;
Stanzl, Ursula ;
Haschka, David ;
Asshoff, Malte ;
Dichtl, Stefanie ;
Nairz, Manfred ;
Huber, Eva ;
Stadlinger, Martin ;
Moschen, Alexander R. ;
Li, Xiaorong ;
Pallweber, Petra ;
Scharnagl, Hubert ;
Stojakovic, Tatjana ;
Maerz, Winfried ;
Kleber, Marcus E. ;
Garlaschelli, Katia ;
Uboldi, Patrizia ;
Catapano, Alberico L. ;
Stellaard, Frans ;
Rudling, Mats ;
Kuba, Keiji ;
Imai, Yumiko ;
Arita, Makoto ;
Schuetz, John D. ;
Pramstaller, Peter P. ;
Tietge, Uwe J. F. ;
Trauner, Michael ;
Norata, Giuseppe D. ;
Claudel, Thierry ;
Hicks, Andrew A. ;
Weiss, Guenter ;
Tancevski, Ivan .
CELL METABOLISM, 2014, 20 (05) :787-798
[30]   Hypolipidemic effect of SIPI-7623, a derivative of an extract from oriental wormwood, through farnesoid X receptor antagonism [J].
Deng Yi-Fang ;
Huang Xiao-Ling ;
Su Mei ;
Yu Peng-Xia ;
Zhang Zhen ;
Liu Quan-Hai ;
Wang Guo-Ping ;
Liu Min-Yu .
CHINESE JOURNAL OF NATURAL MEDICINES, 2018, 16 (08) :572-579
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